MODULATION AND REPLETION/ENHANCEMENT OF THE COMPLEMENT SYSTEM FOR TREATMENT OF TRAUMA
First Claim
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1. A method of treating an individual who has suffered a traumatic injury comprising administering a complement activation inhibitor to the individual within 24 hours after the injury, wherein the complement inhibitor (i) acts at or above the level of C3 activation;
- and (ii) does not cause significant depletion or irreversible inactivation of an unactivated complement component.
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Abstract
The present invention features the use of selected complement activation inhibitor(s) for treating an individual who has suffered a severe injury. The complement activation inhibitor acts at or above the level of C3 activation and does not significantly deplete or irreversibly inhibit complement activation. Also provided are compositions and methods for repleting and/or enhancing complement activation capacity in a subject who has suffered a traumatic injury.
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Citations
54 Claims
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1. A method of treating an individual who has suffered a traumatic injury comprising administering a complement activation inhibitor to the individual within 24 hours after the injury, wherein the complement inhibitor (i) acts at or above the level of C3 activation;
- and (ii) does not cause significant depletion or irreversible inactivation of an unactivated complement component.
- View Dependent Claims (2, 3, 5, 20, 21, 22, 23, 24, 25, 26, 38, 41, 44, 53)
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4. (canceled)
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6-19. -19. (canceled)
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27-37. -37. (canceled)
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39-40. -40. (canceled)
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42-43. -43. (canceled)
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45-52. -52. (canceled)
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54-135. -135. (canceled)
Specification