METHODS OF TREATING A MEIOTIC KINESIN ASSOCIATED DISEASE
First Claim
1. A method of treating a meiotic kinesin-associated disease or disorder, comprising administering to a subject in need of treatment thereof an agent which inhibits a meiotic kinesin such that treatment of the disease or disorder is achieved.
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Abstract
The invention provides methods of treating a meiotic kinase-associated disease, preferably the meiotic kinase HSET, by administering an inhibitor of the meiotic kinase. Preferably, the disease is associated with the presence of supernumerary centrosomes, such as cancer. Methods of inhibiting the growth of a tumor cell by contacting the cell with an inhibitor of a meiotic kinase, preferably HSET, are also provided. Screening methods for identifying inhibitors of the meiotic kinase HSET are also provided. Methods of selecting subjects for treatment with an inhibitor of a meiotic kinase, such as HSET, are also provided.
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Citations
42 Claims
- 1. A method of treating a meiotic kinesin-associated disease or disorder, comprising administering to a subject in need of treatment thereof an agent which inhibits a meiotic kinesin such that treatment of the disease or disorder is achieved.
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3-5. -5. (canceled)
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9-11. -11. (canceled)
- 14. A method of inhibiting growth of a tumor cell in which cellular proliferation is associated with a meiotic kinesin, comprising contacting the tumor cell with an agent which inhibits a meiotic kinesin such that growth of the tumor cell is inhibited.
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19-21. -21. (canceled)
- 23. A method of inhibiting proliferation of a cell in which cellular proliferation is associated with a meiotic kinesin, comprising contacting the cell with an agent which inhibits a meiotic kinesin such that inhibition of cell proliferation is achieved.
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25. (canceled)
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28-30. -30. (canceled)
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31. A method for identifying a compound that inhibits activity of a meiotic kinesin HSET, the method comprising
providing an indicator composition comprising the meiotic kinesin HSET; -
contacting the indicator composition with a test compound; and determining activity of the meiotic kinesin HSET in the presence of the test compound, wherein reduction of activity of the meiotic kinesin HSET in the presence of the test compound, as compared to activity of the meiotic kinesin HSET in the absence of the test compound, identifies the test compound as a compound that inhibits the activity of a meiotic kinesin HSET. - View Dependent Claims (32, 33)
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34-36. -36. (canceled)
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37. A method of selecting a subject with a tumor for treatment with an agent which inhibits a meiotic kinesin, the method comprising
(i) obtaining a tumor cell sample from the subject, and (ii) determining centrosome number in the tumor cell sample, wherein the presence of supernumerary centrosomes in the tumor cell sample selects the subject for treatment with an agent which inhibits a meiotic kinesin.
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41. (canceled)
Specification