CURCUMIN NANOPARTICLES AND METHODS OF PRODUCING THE SAME

• US 20110190399A1
• Filed: 07/31/2009
• Published: 08/04/2011
• Est. Priority Date: 07/31/2008
• Status: Abandoned Application

• Current Assignee: Santosh Kumar Kar
• Original Assignee: Santosh Kumar Kar
• Inventors: Akhtar, Feroz, Pandey, Atul Kumar, Kar, Santosh Kumar, Ray, Gopesh
• Application Number:
  US13/056,515
• Publication Number:
  US 20110190399A1
• Time in Patent Office: Days
• US Class Current: 514/679
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 9/0056 Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/5161 Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
• CPC Class Codes: A61P 1/16 for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 33/06 Antimalarials
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2991 Coated

Abstract

The present invention provides for curcumin nanoparticles and curcumin bound to chitosan nanoparticles and methods of producing the same. Bioavailability of curcumin in these formulations was shown to improve by more than 10 fold.

Claims

1. Nano-sized particles of pure curcumin wherein said nano-sized particles comprise about 100% curcumin.

12. The nano-sized particles of pure curcumin as claimed in claim 1, wherein the diameter of said particles ranges between 50 nm to 284 nm.

13. The nano-sized particles of pure curcumin as claimed in claim 1, wherein the mean diameter of said particles is 115 nm.

20. A method of using the curcumin nanoparticles of claim 1 to treat a disease or disorder selected from the group consisting of:

cancers, inflammatory diseases, alzeihmer'"'"'s disease, cholesterol gall stone, diabetes, alcohol and drug induced liver diseases, microbial infections, parasitic infestation, malaria and other parasitic diseases, and neurological disorders comprising providing the curcumin nanoparticles of claim 1 to a subject in need thereof

21. A medicament comprising the curcumin nanoparticles of claim 1.

2-11. -11. (canceled)

14. Nanoparticles comprising curcumin bound to chitosan nanoparticles, wherein said chitosan nanoparticles comprise chemically unmodified chitosan.

15. The nanoparticles as claimed in claim 14 comprising curcumin coated on the surface of chitosan nanoparticles.

16. The nanoparticles as claimed in claim 14, wherein the diameter of the nanoparticles ranges between 43 nm to 84 nm.

17. The nanoparticles as claimed in claim 14, wherein the mean diameter of the nanoparticles is 62.3 nm.

18. A process of preparing nano-sized particles of pure curcumin comprising:

dissolving curcumin in alcohol to obtain a solution comprising curcumin and alcohol; and

spraying said solution comprising curcumin and alcohol at 25 °

C.-40°

C. under a nitrogen atmosphere and high pressure into a second solution comprising a low percentage of an organic acid while stirring at room temperature.

19. A process of preparing nanoparticles comprising curcumin bound to chitosan nanoparticles comprising:

(a) making a clear solution of chitosan in an organic acid by stirring the suspension while heating at 50°

C.-80 °

C.;

(b) rapidly cooling the solution of (a) to 4°

C.-10°

C. and repeating steps (a) and (b);

(c) heating the clear solution at 50°

C.-80°

C. and spraying said clear solution under pressure into water while stirring at 4°

C-10°

C. to obtain chitosan nanoparticles;

(d) preparing a clear solution of curcumin in alcohol and adding it to a stirred aqueous suspension of chitosan nanoparticles in an organic acid and stirring the resulting suspension at room temperature; and

(e) centrifuging the curcumin-chitosan nanoparticles suspension and repeating the process to remove unbound curcumin from the nanoparticles.