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HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS

  • US 20110190613A1
  • Filed: 01/11/2011
  • Published: 08/04/2011
  • Est. Priority Date: 01/11/2010
  • Status: Abandoned Application
First Claim
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1. A method for near-infrared spectrophotometric (NIRS) monitoring of at least one chromophore level in a biological volume of a patient, comprising:

  • determining a non-pulsatile component of an absorption property of the biological volume for each of at least three distinct wavelengths of near-infrared radiation using a phase modulation spectrophotometry (PMS) based measurement method, said PMS-based measurement method being characterized by a relatively high modulation rate and being further characterized in that both amplitude and phase information detected at the relatively high modulation rate are processed to compute said non-pulsatile component of the absorption property;

    processing the measured amplitude and the measured phase information associated with said PMS-based determination of said non-pulsatile component of the absorption property to compute PMS-derived intermediate information that is at least partially representative of a scattering characteristic of the biological volume;

    determining a pulsatile component of the absorption property of the biological volume for each of said at least three distinct wavelengths using a continuous wave spectrophotometry (CWS) based measurement method, said CWS-based measurement method being characterized by a relatively low modulation rate, wherein said determining the pulsatile component of the absorption property comprises processing amplitude information detected at the relatively low modulation rate in conjunction with said PMS-derived intermediate information to compute said pulsatile component of the absorption property;

    computing at least one metric representative of the at least one chromophore level in the biological volume based on said pulsatile component of the absorption property at said at least three wavelengths; and

    displaying said at least one metric on an output display.

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