METHOD AND APPARATUS FOR QUANTIFICATION OF CARDIAC WALL MOTION ASYNCHRONY
First Claim
1. A computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method for analyzing cardiac wall motion of first and second cardiac regions using an echocardiogram, the method comprising:
- receiving regional displacement magnitudes calculated for the first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours detected from the echocardiogram;
generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a plot of regional displacement magnitude verses time over the cardiac cycle;
providing a common magnitude reference to the first and second regional displacement curves;
averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles;
smoothing the averaged first and second regional displacement curves; and
computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the relative phase indicative of a cardiac wall motion asynchrony.
0 Assignments
0 Petitions
Accused Products
Abstract
A phase analysis technique provides for quantification of regional wall motion asynchrony from endocardial border contours generated from two-dimensional echocardiographic ventricular images. The technique produces results including a degree of radial ventricular asynchrony in heart failure patients with ventricular conduction delay to predict a magnitude of contractile function improvement with pacing therapy. Quantification of change in ventricular regional wall motion asynchrony in response to a therapy provides for a means to identify candidates to receive the therapy and quantitatively predict the benefit of the therapy. Quantification of changes in ventricular regional wall motion asynchrony in response to a sequence of therapies provides for a means to determine an approximately optimal therapy for an intended patient response.
-
Citations
27 Claims
-
1. A computer-readable medium having computer-executable instructions to cause a computer or computer-based system to perform a method for analyzing cardiac wall motion of first and second cardiac regions using an echocardiogram, the method comprising:
-
receiving regional displacement magnitudes calculated for the first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours detected from the echocardiogram; generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a plot of regional displacement magnitude verses time over the cardiac cycle; providing a common magnitude reference to the first and second regional displacement curves; averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles; smoothing the averaged first and second regional displacement curves; and computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the relative phase indicative of a cardiac wall motion asynchrony. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A method, comprising:
-
recording an echocardiogram; detecting cardiac wall motion contours from the echocardiogram; calculating regional displacement magnitudes for first and second cardiac regions over one cardiac cycle based on cardiac wall motion contours; generating first and second regional displacement curves based on the regional displacement magnitudes calculated for the first and second cardiac regions, respectively, the first and second regional displacement curves each being a regional displacement magnitude verses time plot over the cardiac cycle; providing a common magnitude reference to the first and second regional displacement curves; averaging each of the first and second regional displacement curves over a predetermined number of cardiac cycles; smoothing the averaged first and second regional displacement curves; and computing a relative phase representing a phase relationship between the first and second regional displacement curves based on a frequency analysis, the relative phase indicative of a degree of cardiac wall motion asynchrony reflected in the echocardiogram. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
Specification