Method and Apparatus for Delivering an Agent to a Kidney

• US 20110190698A1
• Filed: 10/12/2010
• Published: 08/04/2011
• Est. Priority Date: 05/31/2007
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: von Oepen, Randolph, Kramer-Brown, Pamela A., Yribarren, Travis R. JR., Ludwig, Florian, Gale, David C., El-Nounou, Fozan O., Webler, William E. JR., Consigny, Paul M.
• Granted Patent: US 9,144,509 B2
• Time in Patent Office: Days
• US Class Current: 604/103.01
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

Devices for delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These devices have several related structures and are designed to deliver the drugs to facilitate rapid mixing with the blood flowing past the devices.

Claims

1. A device comprising a catheter including

a main body,

an expandable diffusion member comprising a body, and

a drug delivery lumen.

2. The device of claim 1 wherein the expandable diffusion member comprising a body comprises a pre-formed shape memory material.

3. The device of claim 2 wherein the pre-formed shape memory material comprises nitinol.

4. The device of claim 1 wherein the expandable diffusion member comprising a body comprises a net-like, braided structure.

5. The device of claim 4 wherein the net-like, braided structure comprises one, two, or more wires or filaments.

6. The device of claim 1 wherein the expandable diffusion member comprising a body comprises a donut structure.

7. The device of claim 6 wherein the donut structure comprises a substantially cylindrical body with a length, a largest diameter, and a passage coaxial to the cylindrical axis.

8. The device of claim 7 wherein the length ranges from one to ten times the largest diameter of the body.

9. The device of claim 8 wherein the body has a diameter of 50-105% of the vessel.

10. The device of claim 9 wherein the passage has a diameter that ranges from 15-80% of the largest diameter of the cylinder.

11. The device of claim 10 further comprising a connecting member that joins the main body to the expandable diffusion member comprising a body.

12. The device of claim 7 further comprising a connecting member that joins the main body to the expandable diffusion member comprising a body.

13. The device of claim 12 wherein the length ranges from one to ten times the largest diameter of the body.

14. The device of claim 13 wherein the body has a diameter of 50-105% of the vessel.

16. The device of claim 1 wherein the expandable diffusion member has a body with a length wherein the length ranges from one to ten times the largest diameter of the body.

17. The device of claim 7 wherein the body has a diameter of 50-105% of the vessel.

18. The device of claim 7 wherein the passage has a diameter that ranges from 15-80% of the largest diameter of the cylinder.

19. The device of claim 1 wherein the expandable diffusion member comprising a body further comprises a ball of wire or filament.

20. The device of claim 19 wherein the ball of wire or filament comprises a set of coplanar serpentine curves.

21. The device of claim 20 wherein the ball of wire or filament comprises two or more sets of one or more coplanar, serpentine curves each set situated in different planes.

22. The device of claim 21 further comprising two or more sets of one or more coplanar, serpentine curves each set situated in different planes wherein one or more sets of planes are substantially parallel to each other.

23. The device of claim 1 wherein the expandable diffusion member comprising a body further comprises an occlusion balloon.

15. The device of claim 15 wherein the passage has a diameter that ranges from 15-80% of the largest diameter of the cylinder.