REMOTE ISCHEMIC CONDITIONING FOR TREATMENT AND PREVENTION OF RESTENOSIS

• US 20110190807A1
• Filed: 02/01/2011
• Published: 08/04/2011
• Est. Priority Date: 02/01/2010
• Status: Abandoned Application

• Current Assignee: Hospital For SICK Children
• Original Assignee: Hospital For SICK Children
• Inventors: CALDARONE, CHRISTOPHER, REDINGTON, ANDREW
• Application Number:
  US13/018,664
• Publication Number:
  US 20110190807A1
• Time in Patent Office: Days
• US Class Current: 606/201
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2205/067 Fingers
• CPC Class Codes: A61H 23/04 with hydraulic or pneumatic drive hydraulic or Pneumatic massages, A61H9/00; underwater massages, A61H33/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The invention provides methods for reducing the incidence and/or severity of restenosis through the use of remote ischemic conditioning.

Claims

1. A method for reducing restenosis in subject comprising

performing a repeated remote ischemic conditioning (RIC) regimen on a subject having or at risk of developing restenosis, in an amount and a frequency sufficient to reduce the incidence or severity of restenosis.

2. The method of claim 1, wherein restenosis occurs following a medical intervention.

3. The method of claim 1, wherein the repeated RIC regimen comprises more than one RIC regimen performed on a single day.

5. The method of claim 1, wherein the repeated RIC regimen comprises one or more RIC regimens on more than one day.

6. The method of claim 5, wherein the repeated RIC regimen comprises one or more RIC regimens performed on a daily basis for one month.

7. The method of claim 5, wherein the repeated RIC regimen comprises one or more RIC regimens performed every other day for one month.

10. The method of claim 1, wherein the subject is human.

11. The method of claim 1, wherein the subject will receive a medical intervention.

12. The method of claim 11, wherein the repeated RIC regimen is performed before the medical intervention.

13. The method of claim 11, wherein the repeated RIC regimen is performed during the medical intervention.

14. The method of claim 11, wherein the repeated RIC regimen is performed after the medical intervention.

15. The method of claim 11, wherein the repeated RIC regimen is performed before and after the medical intervention.

16. The method of claim 1, wherein the medical intervention is an intravascular stent placement.

21. The method of claim 11, wherein the medical intervention is angioplasty.

22. The method of claim 11, wherein the medical intervention is a non-vascular stent placement.

24. The method of claim 11, wherein at least one RIC regimen is performed within 24 hours of the medical intervention.

27. The method of claim 1, wherein at least one RIC regimen comprises at least four cycles, each cycle comprising supra-systolic pressure and reperfusion.

28. The method of claim 1, wherein at least one RIC regimen comprises more than one cycle comprising 5 minutes of supra-systolic pressure and 5 minutes of reperfusion.

29. The method of claim 27, wherein the supra-systolic pressure is a pressure that is at least 15 mmHg above systolic pressure.

30. The method of claim 1, wherein the repeated RIC regimen is performed at the same site.

4. (canceled)

8-9. -9. (canceled)

17-20. -20. (canceled)

23. (canceled)

25-26. -26. (canceled)

31-34. -34. (canceled)