Flow Distribution Mixer

• US 20110192217A1
• Filed: 02/08/2010
• Published: 08/11/2011
• Est. Priority Date: 02/08/2010
• Status: Active Grant

• Current Assignee: Aglient Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Baeuerle, Martin, Witt, Klaus, Choikhet, Konstantin
• Granted Patent: US 8,511,889 B2
• Time in Patent Office: Days
• US Class Current: 73/61.55
• CPC Class Codes: B01F 25/432 with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
• CPC Class Codes: B01F 25/433 Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
• CPC Class Codes: B01F 25/4331 Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: G01N 2030/347 mixers
• CPC Class Codes: G01N 30/34 of fluid composition, e.g. gradient G01N30/36 takes precedence

Abstract

A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel.

Claims

1. A mixer for mixing a fluid having a property varying along a flow direction of the fluid, the mixer comprising:

an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet,

a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and

a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow,

wherein

each flow channel comprises a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel,

one or more of the flow channels each comprise a second flow section coupled in series with the first flow section of the respective flow channel,

each second flow section comprises a volume that is flown through by the fluid and delays fluid propagation from the first flow section to the flow combiner by a time required by the respective partial flow to pass the volume of the respective second flow section, and

the distribution of the partial flows into the flow channels is substantially independent of the viscosity of the fluid.

2. The mixer of claim 1, comprising at least one of:

the hydraulic resistance of each of the plurality of flow channels is substantially equal;

the volume of the second flow section is significantly larger than a volume of the first flow section of the respective flow channel;

the distribution of the partial flows into the flow channels is substantially independent of the viscosity of the fluid at any moment in time.

3. The mixer of claim 1, comprising at least one of:

the flow distributor distributes the fluid into the first flow sections of the plurality of flow channels;

the flow distributor substantially simultaneously distributes the fluid into the first flow sections;

a variation of the property of the fluid arrives substantially simultaneously at the first flow sections.

4. The mixer of claim 1, comprising at least one of:

the flow-through times of the partial flows through the first flow sections are substantially equal;

the flow-through times of the partial flows through the first flow sections are substantially neglectable to a characteristic duration of a variation of the varying property of the fluid;

the flow-through times of the partial flows through the first flow sections are substantially equal and neglectable to a characteristic duration of a variation of the varying property of the fluid;

the flow-through time of each partial flow through the respective first flow section is smaller than a characteristic duration of a variation of the varying property of the fluid.

5. The mixer of claim 1, comprising at least one of:

a plurality of the second flow sections each has a different volume for delaying the partial flow of the respective flow channel by a different time period;

the volume of each of a plurality of the second flow sections is configured so that the output flow has a desired flow delay profile with respect to the input flow;

the volume of each second flow section is significantly larger than a volume of the first flow section of the respective flow channel.

6. The mixer of claim 1, comprising at least one of:

one or more of the second flow sections each comprises a chamber;

one or more of the second flow sections each comprises a plurality of chambers arranged sequentially in the flow direction of the fluid and having a total volume being significantly larger than a volume of the first flow section of the respective flow channel.

7. The mixer of claim 1, wherein:

one or more of the second flow sections each comprises a plurality of chambers arranged sequentially in the flow direction of the fluid, wherein successive chambers are coupled by a respective connecting section.

8. The mixer of claim 7, comprising at least one of:

each chamber has an average cross section being significantly larger than an average cross section of a respective connecting section coupled to such chamber;

each chamber has a chamber volume being significantly larger than a volume of a respective connecting section coupled to such chamber;

wherein a plurality of the connecting sections are arranged with respect to the respective chambers to force the fluid to flow at varying angles with respect to direction of gravitational force.

9. The mixer of claim 1, wherein

one or more of the second flow sections each comprises at least one direction change element configured for changing the flow direction of the fluid.

10. The mixer of claim 9, wherein

the direction change element comprises at least one first subsection having a first direction of flow of the fluid, and at least one second subsection having a second direction of flow of the fluid, the first direction of flow being inclined with respect to the second direction of flow.

11. The mixer of claim 10, comprising at least one of:

the first direction of flow is vertical and the second direction of flow is horizontal;

at least one of the first and second directions of flow has a direction component in the direction of gravitational force.

12. The mixer of claim 1, comprising at least one of:

each flow channel comprises a respective first flow section and a respective second flow section coupled in series, the hydraulic resistance of the first flow section being significantly larger than a hydraulic resistance of the second flow section thus dominating the hydraulic resistance of the flow channel;

the hydraulic resistance of the first flow section is in the range of 2-100000 times, preferably 5-500 times, and more preferably about −

100 times, larger than the hydraulic resistance of the second flow section;

in each flow channel, a first cross section of the first flow section is significantly smaller than a second cross section of the second flow section thus dominating the hydraulic resistance of the flow channel.

13. The mixer of claim 1, comprising at least one of:

each first flow section is substantially equal in length in flow direction of the fluid;

the fluid is at least one of a liquid and a gas;

the varying property of the fluid is at least one of a physical and chemical property varying along the flow direction of the fluid;

the varying property of the fluid is at least one of temperature, composition, viscosity, and elution strength varying along the flow direction of the fluid.

15. A fluid separation system for separating compounds of a sample fluid in a mobile phase, the fluid separation system comprising:

a mobile phase drive configured to drive the mobile phase through the fluid separation system,

a separation unit configured for separating compounds of the sample fluid in the mobile phase,

a mixer according to claim 1.

16. The fluid separation system of claim 15, further comprising at least one of:

the mixer is arranged in a flow path between the mobile phase drive and the separation unit;

a sample injector configured to introduce the sample fluid into the mobile phase;

a detector configured to detect separated compounds of the sample fluid;

a collection unit configured to collect separated compounds of the sample fluid;

a data processing unit configured to process data received from the fluid separation system;

a degassing apparatus configured for degassing the mobile phase.

14. A mixer for mixing a fluid having a property varying along a flow direction of the fluid, the mixer comprising:

an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet,

a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow,

wherein

each flow path comprises a flow direction change forcing the fluid to flow at varying angles with respect to a direction of gravitational in the consequent sub-sections of the flow path.