Process For Hydrophilizing Surfaces Of Fluidic Components And Systems
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Abstract
A method for applying reactive films containing solids to microporous membranes is provided wherein the membrane is firstly moistened and the reactive film containing solids is applied to the membrane while it is still moist. Membranes produced in this manner can contain reactive films having a high proportion of film openers and can be used advantageously in diagnostic elements for detecting constituents and, in particular, large hydrophobic analytes in body fluids.
21 Citations
23 Claims
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1-15. -15. (canceled)
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16. A microporous, absorbent, blood-separating membrane having a reactive film coated thereon, wherein the reactive film is a water-resistant, water-insoluble film which contains
(a) all or at least portions of a detection reagent for an analyte to be detected in a hydrophobic matrix of film formers and (b) film openers comprising inorganic or organic particulate, water insoluble, wettable fillers which do not substantially scatter light and which enable large molecules and cells to penetrate into said reactive film, wherein the mass ratio of film opener to film former is about 10: - 1 to about 1.1.
- View Dependent Claims (17, 18, 19, 20, 22, 23)
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21. (canceled)
Specification