COMPOSITIONS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE
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0 Petitions
Accused Products
Abstract
Compositions and methods for the stimulating, enhancing or promoting an immune response in a host are provided. One embodiment provides methods and compositions for stimulating, enhancing, or promoting an immune response in a host by administering an effective amount of a B7-H4 antagonist, preferably sH4 or variant thereof. Compositions of sH4 can be used to enhance an immune response to treat infection, cancer, or as part of a vaccine.
100 Citations
33 Claims
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1-9. -9. (canceled)
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10. A method for stimulating or enhancing an immune response in an individual comprising
administering to the individual an effective amount of (a) monomeric, soluble B7-H4 consisting of the extracellular domain of B7-H4; - or
(b) a variant of (a) comprising a conservative substitution. - View Dependent Claims (14, 17, 18, 19, 30, 32, 33)
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11-13. -13. (canceled)
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15-16. -16. (canceled)
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20-24. -24. (canceled)
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25. A method for treating cancer comprising
administering to a subject an effective amount of (a) monomeric, soluble B7-H4 consisting of the extracellular domain of B7-H4; - or
(b) a variant of (a) comprising a conservative substitution. - View Dependent Claims (27, 28, 29, 31)
- or
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26. (canceled)
Specification