INJECTABLE NANOPARTICULATE OLANZAPINE FORMULATIONS
7 Assignments
0 Petitions
Accused Products
Abstract
Described are injectable formulations of nanoparticulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise nanoparticulate olanzapine.
-
Citations
31 Claims
-
1-18. -18. (canceled)
-
19. A method of making an injectable nanoparticulate olanzapine composition that produces an intramuscular depot upon administration comprising:
contacting particles of olanzapine or a salt thereof with at least one surface stabilizer for a time and under conditions sufficient to provide an olanzapine composition having an effective average particle size that results in a therapeutic efficacy of about one week or greater, wherein the effective average particle size is between about 300 nm and about 5000 nm. - View Dependent Claims (20, 22)
-
21. (canceled)
-
23. A method for the treatment of a subject for disorders of the central nervous system comprising administering to the subject an effective amount of an injectable composition comprising:
-
(a) olanzapine nanoparticles having an effective average particle size that results in a therapeutic efficacy of about one week or greater; (b) at least one surface stabilizer; and (c) at least one pharmaceutically acceptable carrier; wherein the effective average particle size is between about 300 nm and about 5000 nm. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31)
-
-
24. (canceled)
Specification