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METHODS OF NORMALIZING MEASURED DRUG CONCENTRATIONS AND TESTING FOR NON-COMPLIANCE WITH A DRUG TREATMENT REGIMEN

  • US 20110195520A1
  • Filed: 02/11/2010
  • Published: 08/11/2011
  • Est. Priority Date: 02/11/2010
  • Status: Abandoned Application
First Claim
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1. A method of detecting non-compliance with a prescribed opioid regimen in a subject, comprising:

  • (a) providing a subject that is prescribed a daily dose of said opioid;

    (b) determining a normalized level of said opioid in fluid of the subject;

    (c) developing, in a population that does not include said subject, normalized reference opioid levels and confidence intervals corresponding to each of a plurality of daily doses of said opioid;

    (d) comparing the normalized level of said opioid in the fluid of said subject to the normalized reference opioid level corresponding to the prescribed daily dose of said opioid;

    (e) identifying the subject as non-compliant if the normalized level of said opioid in the fluid of said subject falls outside the confidence interval determined in step (c) corresponding to the subject'"'"'s prescribed daily dose.

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