Systems, devices, and methods including multi-harmonic optical detection of hemozoin nanoparticles
First Claim
Patent Images
1. A system, comprising:
- an energy-emitting component configured to interrogate at least one focal volume with a spatially-patterned pulsed multiplexed electromagnetic energy stimulus;
circuitry configured to detect nonlinear multi-harmonic response energy associated with hemozoin nanoparticles within the at least one focal volume interrogated by the spatially-patterned pulsed multiplexed electromagnetic energy stimulus; and
circuitry configured to compare information associated with the detected nonlinear multi-harmonic response energy to a reference hemozoin response profile.
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Abstract
Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.
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Citations
90 Claims
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1. A system, comprising:
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an energy-emitting component configured to interrogate at least one focal volume with a spatially-patterned pulsed multiplexed electromagnetic energy stimulus; circuitry configured to detect nonlinear multi-harmonic response energy associated with hemozoin nanoparticles within the at least one focal volume interrogated by the spatially-patterned pulsed multiplexed electromagnetic energy stimulus; and circuitry configured to compare information associated with the detected nonlinear multi-harmonic response energy to a reference hemozoin response profile. - View Dependent Claims (8, 9, 15, 16, 17, 19, 20, 22, 25, 29, 34, 35, 37, 40, 47, 48, 49, 51, 52, 53, 54)
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2-7. -7. (canceled)
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60. A method for detecting a condition associated with plasmodium-infected erythrocytes, comprising:
comparing, via circuitry, a nonlinear multi-harmonic response profile associated with at least one focal volume interrogated with a spatially-patterned pulsed electromagnetic energy stimulus to reference hemozoin nonlinear response information. - View Dependent Claims (65)
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61-64. -64. (canceled)
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66-69. -69. (canceled)
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70. A method, comprising:
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interrogating at least one focal volume suspected of containing hemozoin, with a spatially-patterned pulsed electromagnetic energy stimulus; and comparing, using circuitry, information associated with a nonlinear multi-harmonic response of the at least one focal volume suspected of containing hemozoin, to information associated with a reference hemozoin nonlinear response. - View Dependent Claims (71, 72)
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73. A method, comprising:
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eliciting a nonlinear multi-harmonic response from hemozoin nanoparticles in a biological tissue within a focal volume by interrogating the focal volume with a pulsed electromagnetic energy stimulus having a resolution [0.61*(peak emission wavelength/numerical aperture)] ranging from about 300 nanometers to about 10 micrometers; and comparing, using circuitry, the nonlinear multi-harmonic response to reference hemozoin nonlinear response information configured as a physical data structure. - View Dependent Claims (74)
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75-79. -79. (canceled)
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80. A hemozoin-monitoring device, comprising:
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a sensor component configured to detect a nonlinear multi-harmonic response profile associated with hemozoin nanoparticles in a biological tissue within multiple focal volumes interrogated by a pulsed electromagnetic energy stimulus; one or more computer-readable storage media including executable instructions stored thereon that, when executed on a computer, instruct a controller to retrieving from storage one or more parameters associated with reference hemozoin nonlinear response information, and to perform a comparison of a detected nonlinear multi-harmonic response profile to the retrieved one or more parameters; and a transceiver configured to concurrently or sequentially transmit or receive information. - View Dependent Claims (83)
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86. A medical diagnostic device, comprising:
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circuitry configured to generate a multiplexed pulsed electromagnetic energy stimulus having a peak power ranging from about 400 gigawatts to about 8 terawatts; circuitry configured to direct the multiplexed pulsed electromagnetic energy stimulus on a plurality of focal volumes in a biological subject; and circuitry configured to detect a multi-harmonic response associated with a plurality of hemozoin nanoparticles in a biological tissue within one or more of the plurality of focal volumes interrogated by the multiplexed pulsed electromagnetic energy stimulus. - View Dependent Claims (87)
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88. (canceled)
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90. (canceled)
Specification