Systems, devices, and methods including a dark-field reflected-illumination apparatus
First Claim
Patent Images
1. An apparatus, comprising:
- a dark-field illuminator havinga body structure defining at least one aperture,a plurality of interrogators each comprising a waveguide assembly including one or more electromagnetic energy waveguides configured to be coupled to at least one electromagnetic energy emitter, the plurality of interrogators oriented to focus electromagnetic energy onto at least one focal region within the least one aperture at one or more angles of incidence relative to an optical axis of an optical assembly, anda plurality of sensors configured to capture scattered electromagnetic energy from a sample interrogated by the dark-field illuminator.
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Abstract
Systems, devices, and methods are described for providing a monitor or treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection.
107 Citations
42 Claims
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1. An apparatus, comprising:
a dark-field illuminator having a body structure defining at least one aperture, a plurality of interrogators each comprising a waveguide assembly including one or more electromagnetic energy waveguides configured to be coupled to at least one electromagnetic energy emitter, the plurality of interrogators oriented to focus electromagnetic energy onto at least one focal region within the least one aperture at one or more angles of incidence relative to an optical axis of an optical assembly, and a plurality of sensors configured to capture scattered electromagnetic energy from a sample interrogated by the dark-field illuminator. - View Dependent Claims (2, 3, 4, 5, 6, 9, 10, 12, 13, 16)
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7. (canceled)
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8. (canceled)
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11. (canceled)
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14. (canceled)
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15. (canceled)
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17-19. -19. (canceled)
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20. A malaria detection apparatus, comprising:
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an optical assembly having a sample side, a detector side, and an optical axis therethrough; and a dark-field illuminator proximate the sample side of the optical assembly, the dark-field illuminator including a plurality of waveguide assemblies, a sensor component including one or more sensors configured to receive scattered electromagnetic energy from a sample interrogated by the dark-field illuminator, and a body structure having at least one aperture aligned along an axis substantially parallel to an optical axis - View Dependent Claims (21, 22, 23, 24, 25, 31)
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26-30. -30. (canceled)
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32. A dark-field illuminator, comprising:
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a body structure defining at least one aperture; a plurality of interrogators each comprising a waveguide assembly including one or more electromagnetic energy waveguides configured to be coupled to at least one electromagnetic energy emitter, the plurality of interrogators oriented to focus electromagnetic energy onto at least one focal region within the least one aperture at one or more angles of incidence relative to an optical axis of an optical assembly; and a plurality of sensors configured to capture scattered electromagnetic energy from a sample interrogated by the dark-field illuminator. - View Dependent Claims (33, 34, 36)
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35. (canceled)
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37. (canceled)
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38. (canceled)
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39. A dark-field illuminator system, comprising:
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an interrogation stimulus circuit configured to direct an electromagnetic energy stimulus onto one or more focal volumes of a sample; and a detection circuit configured to acquire scattered electromagnetic energy from a sample interrogated by the interrogation stimulus circuit at one or more angles of incidence. - View Dependent Claims (41, 42)
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40. (canceled)
Specification