DEVICES AND METHODS FOR LUMEN TREATMENT

• US 20110196478A1
• Filed: 02/10/2011
• Published: 08/11/2011
• Est. Priority Date: 02/10/2010
• Status: Abandoned Application

• Current Assignee: Beoptima, Inc.
• Original Assignee: Beoptima, Inc.
• Inventors: Torosoff, Mikhail T.
• Application Number:
  US13/024,981
• Publication Number:
  US 20110196478A1
• Time in Patent Office: Days
• US Class Current: 623/1.36
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems

Abstract

Devices and methods for lumen treatment are provided. According to aspects illustrated herein, there is provided an endoprosthesis that includes an internal layer designed to provide a negative electric field directed endoluminally; an external layer designed to provide a positive electric field directed exoluminally; and one or more intermediate layers disposed between the internal layer and the external layer, wherein the negative electric field is due to a negative point charge between about −25 mV and about −250 mV, and wherein the positive electric field is due to a positive point charge between about +1 mV and about +30 mV.

Claims

1. An endoprosthesis comprising:

an internal layer designed to provide a negative electric field directed endoluminally;

an external layer designed to provide a positive electric field directed exoluminally; and

one or more intermediate layers disposed between the internal layer and the external layer,

wherein the negative electric field is due to a negative point charge between about −

25 mV and about −

250 mV, and

wherein the positive electric field is due to a positive point charge between about +1 mV and about +30 mV.

2. The endoprosthesis of claim 1, wherein the negative electric field is directed endoluminally in both a radial direction and a longitudinal direction.

3. The endoprosthesis of claim 1, wherein the negative electric field is dispersed at an angle more than about 180 degrees.

4. The endoprosthesis of claim 1, wherein the negative electric field blankets an inside surface of the endoprosthesis substantially in its entirety.

5. The endoprosthesis of claim 1, wherein the positive electric field is directed exoluminally in a radial direction.

6. The endoprosthesis of claim 1, wherein the positive electric field is dispersed at an angle less than about 120 degrees.

7. The endoprosthesis of claim 1, wherein the material that provides the negative point charge is capable of maintaining the negative point charge for a period of at least six weeks.

8. The endoprosthesis of claim 1, wherein the internal layer comprises a metal capable of providing a charge between about −

150 mV and about −

250 mV.

9. The endoprosthesis of claim 1, wherein the internal layer comprises an isotope capable of providing a charge between about −

25 mV and about −

200 mV.

10. The endoprosthesis of claim 1, wherein the external layer comprises a metal capable of providing a charge between about +1 mV and about +30 mV.

11. An endoprosthesis comprising:

a plurality of struts, wherein each strut has an internal layer, an external layer, and one or more intermediate layers therebetween,

wherein the internal layer includes a material that provides a negative electric field directed endoluminally,

wherein the external layer includes a material that provides a positive electric field directed exoluminally, and

wherein the one or more intermediate layers include a material that provides an insulation between the internal layer and the external layer.

12. The endoprosthesis of claim 11, wherein the negative electric field is created by a negative point charge between about −

150 mV and about −

250 mV.

13. The endoprosthesis of claim 11, wherein the positive electric field is created by a positive point charge between about +1 mV and about +30 mV.

14. The endoprosthesis of claim 11, wherein the struts are designed such that the negative electric field is dispersed at an angle less than about 180 degrees

15. The endoprosthesis of claim 11, wherein the struts are designed such that the negative electric field blankets an inside surface of the endoprosthesis substantially in its entirety.

16. The endoprosthesis of claim 11, wherein the struts are designed such that the positive electric field is directed in a radial direction.

17. The endoprosthesis of claim 11, wherein the struts are designed such that the positive electric field is dispersed at an angle less than about 120 degrees.

18. A method of treating a blood vessel comprising:

deploying an endoprosthesis inside the blood vessel, the endoprosthesis comprising;

an internal layer designed to provide a negative electric field directed endoluminally;

an external layer designed to provide a positive electric field directed exoluminally; and

one or more intermediate layers disposed between the internal layer and the external layer,

wherein the negative electric field is created by a negative point charge between about −

25 mV and about −

250 mV, and

wherein the positive electric field is created by a positive point charge between about +1 mV and about +30 mV so as to treat the blood vessel.

19. The method of claim 18, wherein the one or more intermediate layers comprises a stent.

20. The method of claim 19, wherein the one or more intermediate layers include a material that provides an insulation between the internal layer and the external layer