METHOD AND APPARATUS FOR REMOTELY PERFORMING HEMATOLOGIC ANALYSIS UTILIZING A TRANSMITTED IMAGE OF A CENTRIFUGED ANALYSIS TUBE

• US 20110200239A1
• Filed: 01/28/2011
• Published: 08/18/2011
• Est. Priority Date: 02/17/2010
• Status: Active Grant

• Current Assignee: QBC Diagnostics, LLC, Robert A. Levine
• Original Assignee: Robert A. Levine
• Inventors: Wardlaw, Stephen C., Levine, Robert A., Clipper, David A., Stout, Craig, Levine, Joshua D.
• Granted Patent: US 8,774,487 B2
• Time in Patent Office: Days
• US Class Current: 382/128
• CPC Class Codes: B01L 2300/027 Digital display, e.g. LCD, LED
• CPC Class Codes: B01L 2300/0609 Holders integrated in container to position an object
• CPC Class Codes: B01L 2300/0654 Lenses; Optical fibres
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 3/50215 using a float to separate phases
• CPC Class Codes: B01L 9/065 specially adapted for capillary tubes
• CPC Class Codes: G01N 15/042 by centrifuging and investigating centrifugates centrifuges per se B04B
• CPC Class Codes: G01N 15/05 in blood
• CPC Class Codes: G01N 2015/045 by optical analysis
• CPC Class Codes: G01N 2800/22 Haematology
• CPC Class Codes: G01N 33/491 by separating the blood components G01N15/05 takes precedence
• CPC Class Codes: G06T 2207/30024 Cell structures in vitro; Tissue sections in vitro
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

An apparatus for and method of analyzing hematologic samples deposited within a capillary tube is provided. The method includes the steps of: a) imaging a region of sample centrifuged within a capillary tube using a first analysis device, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, and producing signals representative of the image; b) communicating the signals representative of the image to a second analysis device independent of, and remotely located from, the first analysis device; c) processing the signals representative of the image using the second analysis device and producing analysis data based on the signals; and d) displaying the image of the region of the sample using the second analysis device.

Claims

1. A system for analyzing a hematologic sample centrifuged within a capillary tube, which tube has an internal compartment with a radial width and an axial length and a float disposed within the tube, the device comprising:

at least one first analysis device that includes a tube holder, a sample imaging device adapted to create a digital image of the sample within a region of the tube, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, and the sample imaging device is adapted to produce signals representative of the image; and

a second analysis device adapted to be remotely located from the first analysis device, and adapted to communicate with the first analysis device, including receiving the signals representative of the image, which second analysis device includes a processor adapted to produce information relating to bands of interest within the image based on the signals, and a sample data display adapted to display the digital image of the sample within the region.

2. The system of claim 1, wherein the first analysis device includes a processor adapted to produce information relating to bands of interest within the image based on the signals from the sample imaging device.

3. The system of claim 2, wherein the processor of the first analysis device is adapted to selectively lock out unauthorized operators.

4. The system of claim 2, wherein processor of the first analysis device is adapted to transmit the signals representative of the image to the second analysis device in the event an anomaly within the image is detected by the processor of the first analysis device.

5. The system of claim 1, wherein the second analysis device is adapted to send the information relating to bands of interest within the image to one or both of the first analysis device and a remote portal.

6. The system of claim 1, wherein the sample imaging device is a digital camera.

7. The system of claim 6, wherein the digital camera is operable to create a single image of the region of the tube, wherein the region is defined by substantially all of the width and axial length of the sample within the tube.

8. The system of claim 1, wherein the first analysis device is adapted to send the signals representative of the image to the second analysis device on a periodic basis.

9. The system of claim 1, wherein the first analysis device is adapted to send the signals representative of the image to the second analysis device on a use basis.

10. A method of analyzing hematologic samples deposited within a capillary tube, which tube has an internal cavity with a radial width and an axial length, and a float disposed within the tube, the method comprising the steps of:

imaging a region of a sample centrifuged within a capillary tube using a first analysis device, which region is defined by substantially all of the radial width and axial length of the sample residing within the internal cavity of the tube where the float resides after centrifugation, which region includes constituent bands of the sample, and producing signals representative of the image;

communicating the signals representative of the image to a second analysis device independent of, and remotely located from, the first analysis device;

processing the signals representative of the image using the second analysis device and producing analysis data based on the signals; and

displaying the image of the region of the sample using the second analysis device.

11. The method of claim 10, further comprising the step of communicating the analysis data to the first analysis device.

12. The method of claim 10, further comprising the step of evaluating the analysis data for quality control and producing quality control data.

13. The method of claim 12, further comprising the step of communicating the quality control data to the first analysis device.

14. The method of claim 10, further comprising the step of processing the signals representative of the image using the first analysis device and producing analysis data based on the signals, and communicating the analysis data to the second analysis device.

15. The method of claim 14, further comprising the step of requiring an operator authorization prior to releasing or reporting results based upon the signals representative of the image using the first analysis device.

16. The method of claim 14, further comprising the step of evaluating the signals representative of the image using the first analysis device for an anomaly within the image and communicating the presence of the anomaly to the second analysis device in the event an anomaly within the image is detected.

17. The method of claim 14, further comprising the step of periodically sending the signals representative of the image to the second analysis device.

18. The method of claim 14, further comprising the step of sending the signals representative of the image to the second analysis device on a use basis.

19. The method of claim 10, wherein the step of imaging the region of sample includes imaging substantially all of the width and axial length of the sample within the tube.

20. The method of claim 10 further comprising the step of communicating data relating to the analysis to a portal located remotely from the first and second analysis devices.