Systems and methods that kill infectious agents (bacteria) without the use of a systemic anti-biotic
First Claim
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1. A medical product, comprising:
- a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and
a coating that includes at least one of, a non-antibiotic, antimicrobial and/or antiviral substance that prevents further local, non-systemic, colonization of infections.
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Abstract
A medical product is provided that is selected from at least one of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body. A coating is included with at least one of, a non-antibiotic, antimicrobial and/or antiviral substance that prevents further local, non-systemic, colonization of infections.
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Citations
78 Claims
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1. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and a coating that includes at least one of, a non-antibiotic, antimicrobial and/or antiviral substance that prevents further local, non-systemic, colonization of infections. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and a coating including a polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, x being an integer .gtoreq.1, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another, wherein E is at least one of a non-antibiotic, antimicrobial and/or antiviral agent. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and a material coupled to the medical product, the material including one or more non-hydrolyzable, non-leachable polymer chains covalently bonded by non-siloxane bonds to the substrate;
wherein the non-hydrolyzable, non-leachable polymer chains comprise a multitude of antimicrobial groups attached to the non-hydrolyzable, non-leachable polymer chains by covalent bonds; and
wherein a sufficient number of the non-hydrolyzable, non-leachable polymer chains are covalently bonded to sites of the substrate to render the material antimicrobial, or receptive to avid binding of negatively charged dye molecules, when exposed to aqueous fluids, menses, bodily fluids, skin, cosmetic compositions, or wound exudates, wherein the material has associated therewith a plurality of anionically charged biologically or chemically active compounds. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and a superabsorbent material for absorbing biological fluids coupled to the medical product, the superabsorbent material including one or more non-hydrolyzable, non-leachable polymer chains covalently bonded by non-siloxane bonds to the substrate;
wherein the non-hydrolyzable, non-leachable polymer chains comprise a multitude of antimicrobial groups attached to the non-hydrolyzable, non-leachable polymer chains by covalent bonds; and
wherein a sufficient number of the non-hydrolyzable, non-leachable polymer chains are covalently bonded to sites of the flexible substrate to render the material antimicrobial when exposed to aqueous fluids, menses, bodily fluids, or wound exudates;
wherein the superabsorbent material is capable of absorbing about 30 or more times its own weight of water or other fluids in a single instance; and
wherein the absorbing capacity is the result of branching or crosslinking of the non-hydrolyzable, non-leachable polymer chains, wherein the material has associated therewith a plurality of anionically charged biologically or chemically active compounds. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
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61. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and an antimicrobial composition coupled to the medical product including a plurality of polymeric molecules of variable lengths bearing antimicrobial groups, wherein the polymeric molecules are covalently, non-leachably bound to the substrate, and wherein the coating, layer, or enhanced surface area exhibits antimicrobial activity due to the presence of the antimicrobial groups; and
c. ionically associated biologically or chemically active compounds which are released from the substrate and coating layer over a period of time. - View Dependent Claims (62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77)
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78. A medical product, comprising:
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a medical product selected from the group of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other gloves, sheaths for endoscopy probes, and medical products that physically touch the body; and an antimicrobial-coated composition coupled to the medical product and including an effective amount of polymeric molecules having a multiplicity of quaternary ammonium groups, wherein the polymeric molecules are non-leachably and covalently bonded to surface sites of the substrate, wherein the polymers do not form using siloxane bonds, and wherein the coating is absorbent of aqueous liquids, and c. associated anionic biologically active or chemically active compound;
whereby the multiplicity of quaternary ammonium groups act to destroy microbes coming in contact with the groups as well as to bind and release the anionic biologically active or chemically active compound.
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Specification