THERAPEUTIC COMPOSITIONS
First Claim
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1. An iRNA duplex agent comprising a first and a second sequence, having at a selected or constrained sequence, a first monomer in the first sequence, and a second monomer in the second sequence, wherein the monomers are selected such that the stability of the pairing of the monomers contributes to a duplex between the first and second sequence that differs from the stability of the pairing between the first or second sequence and a target sequence.
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Abstract
This application relates to therapeutic siRNA agents and methods of making and using the agents.
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21 Claims
- 1. An iRNA duplex agent comprising a first and a second sequence, having at a selected or constrained sequence, a first monomer in the first sequence, and a second monomer in the second sequence, wherein the monomers are selected such that the stability of the pairing of the monomers contributes to a duplex between the first and second sequence that differs from the stability of the pairing between the first or second sequence and a target sequence.
Specification