Reflection-Mode Photoacoustic Tomography Using A Flexibly-Supported Cantilever Beam
First Claim
Patent Images
1. A method for noninvasively imaging biological tissue using a handheld device, said method comprising:
- focusing at least one light pulse into a predetermined area inside an object using a flexure mounted cantilever beam;
receiving acoustic waves emitted by the object in response to the at least one light pulse;
detecting the acoustic waves using a transducer; and
generating an image of the predetermined area inside the object based on a signal generated by the transducer representative of the acoustic waves.
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Abstract
Noninvasively imaging biological tissue using a handheld device. A light pulse is focused into a predetermined area inside an object using a flexibly mounted cantilever beam, acoustic waves emitted by the object in response to the at least one light pulse are detected by a transducer, and an image of the predetermined area inside the object is generated based on a signal generated by the transducer representative of the acoustic waves.
133 Citations
20 Claims
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1. A method for noninvasively imaging biological tissue using a handheld device, said method comprising:
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focusing at least one light pulse into a predetermined area inside an object using a flexure mounted cantilever beam; receiving acoustic waves emitted by the object in response to the at least one light pulse; detecting the acoustic waves using a transducer; and generating an image of the predetermined area inside the object based on a signal generated by the transducer representative of the acoustic waves. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for determining an oxygen metabolic rate (MRO2) within a biological tissue using a handheld device, said method comprising:
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focusing a plurality of multi-wavelength light pulses into a predetermined area inside an object; receiving acoustic waves emitted by the object in response to the at least one light pulse; and determining the MRO2 based on an area of an incoming vessel within the predetermined area, a mean flow velocity of blood in the incoming vessel, and a total concentration of hemoglobin, wherein the area of the incoming vessel and the mean flow velocity are based on measurements obtained by ultrasound imaging, and wherein the total concentration of hemoglobin is based on measurements obtained by the plurality of multi-wavelength light pulses. - View Dependent Claims (8, 9, 10, 11)
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12. A handheld device for use in noninvasive imaging of biological tissue using photoacoustic tomography, said device comprising:
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a laser; an optical assembly configured to focus at least one light pulse emitted by said laser into a predetermined area inside an object; and a transducer configured to detect acoustic waves emitted by the object in response to the at least one light pulse, wherein said optical assembly and said transducer are positioned on a cantilever beam that is flexibly mounted within a closed, liquid-filled container to facilitate one of one-dimensional scanning of the predetermined area inside the object and two-dimensional scanning of the predetermined area inside the object. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification