Medical Device Applications of Nanostructured Surfaces
First Claim
Patent Images
1. A wound dressing comprising:
- a plurality of nanostructures; and
a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web;
wherein the wound dressing is flexible; and
wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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Abstract
This invention provides novel nanofiber enhanced surface area substrates and structures comprising such substrates for use in various medical devices, as well as methods and uses for such substrates and medical devices. In one particular embodiment, methods for enhancing cellular functions on a surface of a medical device implant are disclosed which generally comprise providing a medical device implant comprising a plurality of nanofibers (e.g., nanowires) thereon and exposing the medical device implant to cells such as osteoblasts.
169 Citations
29 Claims
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1. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the wound dressing is flexible; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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2. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the wound dressing is air-penetrable; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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3. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the wound dressing is water-repellent; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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4. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the wound dressing adheres to both dry surfaces and wet surfaces; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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5. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the wound dressing does not chemically bond to the biological tissue surface; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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6. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures are bent, curved, curled, or coiled; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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7. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures have an average length of from about 1 nm to at least about 500 microns; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures comprise nanowires which have a substantially uniform diameter along the length of the nanowire; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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19. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures comprise nanowires which have a non-uniform diameter along the length of the nanowire; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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20. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein a first portion of the plurality of nanostructures have a different size and/or shape than a second portion of the plurality of nanostructures; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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21. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures protrude at least 10 nm above a first surface of the wound dressing; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface. - View Dependent Claims (22, 23, 24, 25, 26, 27)
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28. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein at least a portion of the plurality of nanostructures comprises an average density on one or more surfaces of the wound dressing from about 50 nanostructures per square micron to at least about 100 nanostructures per square micron; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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29. A wound dressing comprising:
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a plurality of nanostructures; and a bandage that includes a fibrous web, wherein at least a portion of the plurality of nanostructures are incorporated within or associated with the fibrous web; wherein the fibrous web includes a woven or non-woven fibrous mat; and wherein a surface of the bandage is capable of adhering to a biological tissue surface due at least to van der Waals forces between at least a portion of the plurality of nanostructures and the biological tissue surface.
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Specification