SYSTEMS AND METHODS RELATING TO POLYMER FOAMS

• US 20110202016A1
• Filed: 08/24/2010
• Published: 08/18/2011
• Est. Priority Date: 08/24/2009
• Status: Abandoned Application

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Arsenal Medical, Inc
• Inventors: Gitlin, Irina, Concagh, Danny, Zugates, Gregory, Kendale, Amar, Carbeck, Jeffrey D., Sharma, Upma
• Application Number:
  US12/862,362
• Publication Number:
  US 20110202016A1
• Time in Patent Office: Days
• US Class Current: 604/290
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

Claims

3. A method, comprising:

foaming and cross-linking a compound represented by formula (I);

16. The method according to claim 3, wherein R₁ and/or Z is substituted with a CO₂ producing group.

17. The method according to claim 3, wherein R₁ and/or Z is substituted with an isocyanate group.

18. The method according to claim 3, where the polymer (I) is cross-linked by a reagent that comprises CO₂ producing groups.

19. The method according to claim 3, where the polymer (I) is cross-linked by a reagent that comprises isocyanate groups.

4. A method limiting movement of a bodily fluid comprising:

foaming and cross-linking a compound with two or more arms represented by formula (II);

9. The method according to claim 4, wherein R₃ contains an isocyanate, carboxylic acid, or carbonate functionality

10. The method according to claim 4, wherein R₂ is an alkoxy.

14. The method according to claim 4, wherein R₃ comprises at least one peptide.

20. The method according to claim 4, wherein R₃ contains a CO₂ producing group.

21-1. The method according to claim 2, wherein the foam does not significantly degrade prior to removing the foam via surgical intervention.

22-2. The method according to claim 2, wherein the polymer comprises a synthetic polymer.

27. The method according to claim 27, comprising non-covalent bonding of the foam to a tissue.

28. A method comprising:

cross-linking a biodegradable polymer;

forming a foam or gel;

placing the polymer between two tissues; and

preventing tissue adhesion.

30. The method according to claim 28, wherein the polymer comprises an isocyanate-functionalized poly(glycerol-sebacate).

31. The method according to claim 28, wherein the polymer comprises formula (II).

34. The method according to claim 28, wherein the polymer is combined with one or more additional polymers.

35. The method according to claim 28, further comprising incorporating drug loaded objects into the resulting gel or foam.

36. The method according to claim 35, wherein the drug loaded objects provide drug release for one or more days.

29. A surgical method comprising:

performing a surgical intervention;

cross-linking a biodegradable polymer;

forming a foam or gel; and

placing the polymer in contact with a tissue affected by the surgical intervention.

32. The method according to claim 29, wherein the polymer comprises an isocyanate-functionalized poly(glycerol-sebacate).

33. The method according to claim 29, wherein the polymer comprises formula (II).