DEVICES, SYSTEMS AND METHODS FOR FLOW-COMPENSATING PUMP-INJECTOR SYNCHRONIZATION
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Abstract
Systems, devices, and methods to mitigate the pressure disturbance associated with the injection of low-pressure analyte samples into a high-pressure HPLC fluid stream, to enhance chromatographic performance related to retention time and reproducibility. The preferred embodiment coordinates the injection run with active pressure control of a binary solvent delivery system to virtually eliminate the customary pressure drop when the low-pressure loop is brought on line. An additional benefit that enhances reproducibility is accomplished by forcing a consistent timing relationship between the injection run, the mechanical position of the delivery pump pistons, and the start and subsequent gradient delivery.
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Citations
56 Claims
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1-38. -38. (canceled)
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39. A control device for a solvent delivery system, the control device being configured to, upon receipt of a start run signal,
signal a dominant flow pump and a non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into a fluid stream; - and then
after a predetermined time delay elapses following receipt of the start run signal, signal the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of an analyte into the fluid stream. - View Dependent Claims (40, 41, 42, 43)
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44. A system comprising:
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an autosample injector operable to inject an analyte into a fluid stream; and a dominant flow pump; a non-dominant flow pump; a control device in communication with the autosample injector, the dominant flow pump, and the non-dominant flow pump, wherein the control device is configured to, upon receipt of a start run signal from the autosample injector, signal the dominant flow pump and the non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into the fluid stream, and then after a predetermined time delay elapses following receipt of the start run signal, signal the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of the analyte into the fluid stream. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52)
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53. A computer-readable medium having encoded thereon software comprising instructions for:
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receiving a start run signal, and, in response, providing a first signal to a dominant flow pump and a non-dominant flow pump to perform a first forced-transfer operation to deliver compressed solvents into a fluid stream; and
thenafter a predetermined time delay elapses following receipt of the start run signal, providing a second signal to the dominant flow pump to perform a second forced-transfer operation to provide a corrective flow of compressed solvent into the fluid stream to counter a pressure drop associated with introduction of an analyte into the fluid stream. - View Dependent Claims (54, 55, 56)
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Specification