×

NOVEL GROUPS OF BIOMARKERS FOR DIAGNOSING ALZHEIMER'S DISEASE

  • US 20110202284A1
  • Filed: 02/10/2011
  • Published: 08/18/2011
  • Est. Priority Date: 02/10/2010
  • Status: Abandoned Application
First Claim
Patent Images

1. A method of aiding diagnosis of Alzheimer'"'"'s disease (“

  • AD”

    ), comprising;

    a) measuring a level of each of at least three AD diagnosis biomarkers in a biological fluid sample in an individual, wherein the at least three AD diagnosis biomarkers are selected from the group consisting of;

    ACE (angiotensin converting enzyme or CD143), alpha-1-antitrypsin, Apo AI (apolipoprotein AI), Apo CIII (apolipoprotein CIII), Apo E (apolipoprotein E), CRP (C-reactive protein), cortisol, FGF-4 (fibroblast growth factor-4), MCP-3 (monocyte chemotactic protein-3), MMP-9 (matrix metalloproteinase-9), and TRAIL R3 (Receptor-3 for Tumor necrosis factor-related apoptosis-inducing ligand)b) implementing a scoring algorithm;

    c) generating a score based on the measured levels of the AD diagnosis biomarkers; and

    d) comparing the score with a cutoff score, wherein the diagnosis of AD is aided by determining whether the score is above, equal to, or below the cutoff score;

    wherein the method has an accuracy of at least about 65% in classifying the individual as either having Alzheimer'"'"'s disease or nondemented.

View all claims
  • 1 Assignment
Timeline View
Assignment View
    ×
    ×