NUTRITIONAL COMPOSITION COMPRISING PROBIOTICS AND IMPROVING SLEEP PATTERNS

• US 20110206649A1
• Filed: 10/29/2009
• Published: 08/25/2011
• Est. Priority Date: 11/03/2008
• Status: Active Grant

• Current Assignee: Societe des Produits Nestle SA (Nestle SA)
• Original Assignee: Nestec SA (Nestle SA)
• Inventors: Bureau-Franz, Isabelle, Bergonzelli Degonda, Gabriela, Garcia-Rodenas, Clara Lucia
• Granted Patent: US 9,034,314 B2
• Time in Patent Office: Days
• US Class Current: 424/93.45
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/31 having an effect on comfort perception and well-being
• CPC Class Codes: A23V 2200/3202 Prebiotics, ingredients fermented in the gastrointestinal tract by beneficial microflora
• CPC Class Codes: A23V 2200/3204 Probiotics, living bacteria to be ingested for action in the digestive tract
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/156 Mineral combination undefined extract A23V2250/1638
• CPC Class Codes: A23V 2250/1882 Polyunsaturated fatty acids
• CPC Class Codes: A23V 2250/70 Vitamins
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 35/742 Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
• CPC Class Codes: A61K 35/744 Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives

Abstract

This invention relates to the use of a probiotic bacterial strain in the manufacture of a medicament or therapeutic nutritional composition for improving the maturation of sleep patterns in infants, young children or young animals and/or for reducing sleep disturbances and/or improving sleep patterns in humans or animals at any age.

Claims

1. A method for reducing sleep disturbances in humans or animals in need of same comprising administering a therapeutically-effective amount of a composition including a probiotic bacterial strain.

2. The method of claim 1 wherein the humans or animals are selected from the group consisting of infants, young animals and young children.

3. The method of claim 1, wherein the humans or animals suffer from poor quality sleep and/or insomnia.

4. The method of claim 1, wherein the composition induces a mature sleep pattern or reduces the number of episodes of wakefulness in the humans or animals.

5. The method of claim 1, wherein the probiotic bacterial strain is selected from the group consisting of lactobacillus and bifidobacterium.

6. The method of claim 5, wherein the lactobacillus is selected from the group consisting of a Lactobacillus rhamnosus species, a Lactobacillus paracasei species and a Lactobacillus reuteri species.

7. The method of claim 5, wherein the bifidobacterium is selected from the group consisting of Bifidobacterium lactis species, a Bifidobacterium longum species, a Bifidobacterium breve species and a Bifidobacterium infantis species.

8. The method of claim 1, wherein the daily dose of probiotic bacteria is from 10³ to 10¹² colony forming units (cfu).

9. The method of claim 1, wherein the composition comprises from 10³ to 10¹² colony forming units (cfu) of probiotic bacteria per g of composition.

10. The method of claim 1, wherein the composition comprises the probiotic bacterial strain in an amount from 10³ to 10¹² cfu/g of the dry composition.

11. The method of claim 1, wherein the composition is a supplement and the probiotic bacterial strain is present in an amount of from 10³ to 10¹² cfu per unit dose.

12. The method of claim 1, wherein the composition is in a form selected from the group consisting of a human milk fortifier, an infant formula, a follow on formula, a growing up milk, an infant cereal, a baby food, a yogurt, a cereal bar, a breakfast cereal, a dessert, a frozen food, a soup, a pet food, a liquid suspension, a powder, a tablet, a gum, a candy, a nutritional composition, and a nutritional supplement.

13. The method of claim 1, wherein the composition induces a more mature sleep pattern.

14. The method of claim 1, wherein the composition comprises carbohydrates, and the carbohydrates comprise rice carbohydrates.

15. The method of claim 1, wherein the composition is a starter infant formula or a follow-up infant formula.

16. A method for improving sleep quality or sleep patterns in humans or animals in need of same comprising administering a therapeutically-effective amount of a composition comprising a probiotic bacterial strain.

17. The method of claim 16 wherein the humans or animals are selected from the group consisting of infants, young animals and young children.

18. The method of claim 16, wherein the humans or animals suffer from poor quality sleep and/or insomnia.

19. The method of claim 16, wherein the composition induces a mature sleep pattern or reduces the number of episodes of wakefulness in the humans or animals.

20. The method of claim 16, wherein the probiotic bacterial strain is selected from the group consisting of lactobacillus and bifidobacterium.

21. The method of claim 20, wherein the lactobacillus is selected from the group consisting of a Lactobacillus rhamnosus species, a Lactobacillus paracasei species and a Lactobacillus reuteri species.

22. The method of claim 20, wherein the bifidobacterium is selected from the group consisting of Bifidobacterium lactis species, a Bifidobacterium longum species, a Bifidobacterium breve species and a Bifidobacterium infantis species.

23. The method of claim 16, wherein the daily dose of probiotic bacteria is from 10³ to 10¹² colony forming units (cfu).

24. The method of claim 16, wherein the composition comprises from 10³ to 10¹² colony forming units (cfu) of probiotic bacteria per g of composition.

25. The method of claim 16, wherein the composition comprises the probiotic bacterial strain in an amount from 10³ to 10¹² cfu/g of the dry composition.

26. The method of claim 16, wherein the composition is a supplement and the probiotic bacterial strain is present in an amount of from 10³ to 10¹² cfu per unit dose.

27. The method of claim 16, wherein the composition is in a form selected from the group consisting of a human milk fortifier, an infant formula, a follow on formula, a growing up milk, an infant cereal, a baby food, a yogurt, a cereal bar, a breakfast cereal, a dessert, a frozen food, a soup, a pet food, a liquid suspension, a powder, a tablet, a gum, a candy, a nutritional composition, and a nutritional supplement.

28. The method of claim 16, wherein the composition induces a more mature sleep pattern.

29. The method of claim 16, wherein the composition comprises carbohydrates, and the carbohydrates comprise rice carbohydrates.

30. The method of claim 16, wherein the composition is a starter infant formula or a follow-up infant formula.