Melamine Assay Methods and Systems
First Claim
1. A method of detecting melamine comprising:
- providing a quantity of SERS-active particles;
mixing a solution containing melamine with the SERS-active particles; and
detecting a surface enhanced Raman spectrum of the melamine.
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Abstract
A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
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Citations
22 Claims
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1. A method of detecting melamine comprising:
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providing a quantity of SERS-active particles; mixing a solution containing melamine with the SERS-active particles; and detecting a surface enhanced Raman spectrum of the melamine. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of detecting melamine comprising:
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providing a quantity of SERS-active particles; providing a quantity of magnetic particles; associating one or more SERS-active particles with one or more magnetic particles; mixing a solution containing melamine with the SERS-active particles and magnetic particles; magnetically concentrating the magnetic particles; and detecting a surface enhanced Raman spectrum of the melamine. - View Dependent Claims (9, 10, 11, 12)
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13. A method of detecting a molecule of interest comprising:
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providing a quantity of SERS-active particles; providing a quantity of a SERS-active standard having a known SERS spectrum; mixing a solution containing the molecule of interest with the SERS-active particles and the SERS-active standard; detecting a surface enhanced Raman spectrum of the molecule of interest; and detecting a surface enhanced Raman spectrum of the SERS-active standard. - View Dependent Claims (14, 15, 16, 17)
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18. An assay system comprising:
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a quantity of SERS-active particles; a quantity of a SERS-active standard; a container for mixing a solution of a molecule of interest with the SERS-active particles and the SERS-active standard; and a SERS reader configured to obtain a SERS spectrum of the molecule of interest and a SERS spectrum of the SERS-active standard. - View Dependent Claims (19, 20, 21, 22)
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Specification