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Glycosylation of Molecules

  • US 20110207676A1
  • Filed: 04/27/2011
  • Published: 08/25/2011
  • Est. Priority Date: 04/03/2007
  • Status: Active Grant
First Claim
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1. A method of producing an altered N-glycosylation form of a target protein, the method comprising:

  • providing a Yarrowia lipolytica or an Arxula adeninivorans cell genetically engineered to comprise a deficiency in Outer CHain elongation (OCH1) activity; and

    introducing into the cell a nucleic acid encoding a target protein, wherein the cell produces the target protein in an altered N-glycosylation form relative to the N-glycosylation form of the target protein produced in a corresponding non-genetically engineered cell.

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