METHODS RELATED TO CASEIN KINASE II (CK2) INHIBITORS AND THE USE OF PURINOSOME-DISRUPTING CK2 INHIBITORS FOR ANTI-CANCER THERAPY AGENTS
First Claim
1. A method for testing a molecule comprising,a) incubating the molecule with a cell system comprising a multienzyme complex forming an incubated cell system,b) assaying the incubated cell system with a label free biosensor system.c) measuring the ability of the molecule to modulate a the multi-enzyme complex.
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Abstract
Disclosed are methods related to label-free biosensor cellular assays to classify multienzyme complex modulators in live cells. Disclosed are also methods related to the identification of purinosome disrupting Casein Kinase II (CK2) inhibitors, and methods related to the use of purinosome disrupting CK2 inhibitors as therapeutic agents for modulating CK2 activity and purine synthesis pathway, and for improving prevention and treatment of CK2 associated cancers, viral infection and inflammation conditions.
58 Citations
43 Claims
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1. A method for testing a molecule comprising,
a) incubating the molecule with a cell system comprising a multienzyme complex forming an incubated cell system, b) assaying the incubated cell system with a label free biosensor system. c) measuring the ability of the molecule to modulate a the multi-enzyme complex.
- 33. A method of treating cancer in a subject comprising administering a purinosome disrupting CK2 inhibitor.
- 36. A method of treating a varial infection in a subject comprising administering a purinosome disrupting CK2 inhibitor.
- 38. A method of treating an inflammation condition in a subject comprising administering a purinosome disrupting CK2 inhibitor.
Specification