Modified Human Plasma Polypeptide or Fc Scaffolds and Their Uses

• US 20110207914A1
• Filed: 02/25/2011
• Published: 08/25/2011
• Est. Priority Date: 09/08/2006
• Status: Abandoned Application

• Current Assignee: Ambrx, Inc. (Johnson & Johnson)
• Original Assignee: Ambrx, Inc. (Johnson & Johnson)
• Inventors: DIMARCHI, Richard D., SHEFFER, Joseph, NORMAN, Thea, KRAWITZ, Denise, CHU, Stephanie, CHO, Ho Sung, HAYS PUTNAM, Anna-Maria A., TIAN, Feng
• Application Number:
  US13/035,719
• Publication Number:
  US 20110207914A1
• Time in Patent Office: Days
• US Class Current: 530/359
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: C07K 14/47 from mammals
• CPC Class Codes: C07K 14/765 Serum albumin, e.g. HSA
• CPC Class Codes: C07K 19/00 Hybrid peptides , i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

Modified human plasma polypeptides or Fc and uses thereof are provided.

Claims

1-76. -76. (canceled)

77. An hPP or hFc comprising one or more non-naturally encoded amino acids linked to apolipoprotein.

78. The hPP or hFC of claim 77, wherein the hPP or hFc further comprises one or more peptides selected from the group consisting of preproinsulin, proinsulin, or pancreatic hormones.

79. The hPP or hFC of claim 78, wherein the pancreatic hormone is selected from the group consisting of insulin, insulin-like peptides, glucagon, somatostatin, pancreatic polypeptides, amylin, peptide YY, and neuropeptide Y.