COUPLED ANTENNA IMPEDANCE SPECTROSCOPY
First Claim
1. ) A process for molecular spectroscopy of a media to determine the concentration of at least one molecular species therein, the process comprising the steps of:
- a) providing a pair of coiled antennas as electrodes for dielectric spectroscopy measurements,b) placing the pair of coiled antenna in signal communication through the media,c) powering at least one of coiled antennas at a first frequency,d) scanning a frequency range during said step of powering from the first frequency to at least a second frequency, the difference between the first and second frequency representing a first frequency range,e) acquiring one or more signals from at least one of the coiled antennas during said step of scanning to determine the value thereof,f) integrating the value of the one or more signals in said step of acquiring, the integration occurring over at least a portion of the first frequency range,g) calculating the concentration of the molecular species from the integrated value of the one or more signals.
1 Assignment
0 Petitions
Accused Products
Abstract
It has been found advantageous to deploy coiled antennas as transmitters and receivers for acquiring the dielectric spectrum of materials. This method of impendence spectroscopy has been used to determine the concentration of glucose and other small polar molecules in vitro, as well as in vivo by placement on the antennas so that transmission is through the tissue, as for example on opposite sides of an organ or body part. The optimum selection of antenna coils permits deeper penetration into tissue for glucose detection, improves the SNR as well as expands the spectral range for greater accuracy and precision, to enable continuous non-invasive monitoring for either improved patient or automated management of diabetes.
21 Citations
20 Claims
-
1. ) A process for molecular spectroscopy of a media to determine the concentration of at least one molecular species therein, the process comprising the steps of:
-
a) providing a pair of coiled antennas as electrodes for dielectric spectroscopy measurements, b) placing the pair of coiled antenna in signal communication through the media, c) powering at least one of coiled antennas at a first frequency, d) scanning a frequency range during said step of powering from the first frequency to at least a second frequency, the difference between the first and second frequency representing a first frequency range, e) acquiring one or more signals from at least one of the coiled antennas during said step of scanning to determine the value thereof, f) integrating the value of the one or more signals in said step of acquiring, the integration occurring over at least a portion of the first frequency range, g) calculating the concentration of the molecular species from the integrated value of the one or more signals. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. ) A device for the in-vivo molecular spectroscopy, the device comprising:
-
a) at least one pair of coiled antennas and configured for placement in signal communication with the other antennas in the pair through a first dielectric medium comprising at least a portion of a living organism, b) a variable frequency power generator in signal communication to each of the antennas in said pair, c) a signal detector in communication to each of the antennas in said pair for collecting transmitted and reflected signals between each of the antennas over the generated frequency range, d) a computation means to determine a plurality of signal propagation constants from the detected signals and calculate the concentration of at least one molecular species there from, wherein the pair of coiled antennas have a first resonance below about 100 MHz and the concentration of the molecular species is calculated by integration of one or more of the plurality of signal propagation constants over a frequency range from a first lower frequency to a second upper frequency wherein the second upper frequency is less than about 1 GHz. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 20)
-
-
16. ) A process to calibrate a device for molecular spectroscopy of a media to determine the concentration of at least one molecular species therein, the process comprising the steps of:
-
a) providing at least one sample media through which a plurality of different concentrations of the molecular species is at least one of known and determinable by independent means of the molecular spectroscopy process, b) providing a pair of coiled antennas as electrodes for dielectric spectroscopy measurements, c) placing the pair of coiled antennas in signal communication through the sample media, d) powering at least one of coiled antennas at a first frequency, e) scanning a frequency range during said step of powering from the first frequency to at least a second frequency, the difference between the first and second frequency representing a first frequency range, f) repeating said step of scanning of the sample media at plurality of times each corresponding to the different concentrations of the molecular species that is at least one of known and determinable by independent means of the molecular spectroscopy process, g) acquiring one or more signals from at least one of the coiled antennas during said steps of repeated scanning to determine the value of a plurality of signal propagation parameters, h) calculating a first correlation product of each of the signal propagation parameters with at least a first subset of the known or determined concentrations of the molecular species, i) calculating at second correlation product of each of the signal propagation parameters with at least a second subset of the known or determined concentrations of the molecular species, the second subset being larger than the first subset, j) comparing the first and second correlation products over the first frequency range, k) identify at least one signal propagation parameter having a selecting regions within the first frequency range wherein the absolute value of the correlation product is greater than about 0.75 over a continuous second frequency range having a width of at least about 50 MHz, l) calculating the integrated value of each signal propagation parameter identified in the previous step over the continuous second frequency associated therewith with provide at least one Q-band parameters, m) calculating the correlation of the at least one Q-band parameter to the known or determined concentrations of the molecular species to provide a calibration equation. - View Dependent Claims (17, 18, 19)
-
Specification