FORMULATIONS AND METHODS FOR NUTRIENT DELIVERY

• US 20110208153A1
• Filed: 02/24/2010
• Published: 08/25/2011
• Est. Priority Date: 02/24/2010
• Status: Abandoned Application

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Alvey, John
• Application Number:
  US12/711,376
• Publication Number:
  US 20110208153A1
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A23L 29/10 containing emulsifiers
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/32 having an effect on the health of the digestive tract
• CPC Class Codes: A23V 2250/1862 Arachidonic acid
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/54242 Alpha lactalbumin
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system

Abstract

The present disclosure provides formulations and methods for delivering water-soluble and lipid-soluble nutrients for preventing or correcting nutrient deficiencies to subjects requiring small-volume nutritional support, such as preterm infants. The formulations may comprise an emulsion of docosahexaenoic acid (DHA) stabilized by a protein emulsifier, such as α-lactalbumin, and may further comprise other valuable nutrients, such as arachidonic acid (ARA), arginine, glutamine, arginyl-glutamine dipeptide and/or alanyl-glutamine dipeptide. The formulation is useful, for example, for correcting nutritional deficiencies by increasing a subject'"'"'s intake of nutrients such as ω-3 or ω-6 long-chain polyunsaturated acids, proteins, peptides, vitamins, minerals, other fatty acids, and/or essential amino acids. The nutritional formulation is suitable for enteral delivery and small-volume delivery via nasogastric tube, intragastric feeding, transpyloric administration and/or any other means of administration that result in the introduction of the nutritional formulation into the digestive tract of a subject.

Claims

1. A nutritional formulation, comprising:

an emulsion comprising docosahexaenoic acid, wherein the emulsion is dispersed in an aqueous component comprising at least one of an amino acid component selected from the group consisting of;

arginine, arginyl-glutamine, and alanyl-glutamine; and

an emulsifier comprising highly-purified α

-lactalbumin.

2. The liquid nutritional formulation of claim 1, wherein the emulsifier comprises at least about 95% w/w of α

-lactalbumin.

3. The liquid nutritional formulation of claim 1, wherein the emulsifier comprises at least about 98% w/w of α

-lactalbumin.

4. The liquid nutritional formulation of claim 1, further comprising at least one prebiotic.

5. The liquid nutritional formulation of claim 1, further comprising vitamins and minerals.

6. The liquid nutritional formulation of claim 1, further comprising at least one ω

-6 fatty acid.

7. The liquid nutritional formulation of claim 1, further comprising arachidonic acid.

8. A method for providing nutritional support to a subject, the method comprising administering to the subject a nutritional formulation comprising:

an emulsion comprising docosahexaenoic acid, wherein the emulsion is dispersed in an aqueous component comprising at least one of an amino acid component selected from the group consisting of;

arginine, arginyl-glutamine, and alanyl-glutamine; and

an emulsifier comprising highly-purified α

-lactalbumin.

9. The liquid nutritional formulation of claim 8, wherein the emulsifier comprises at least about 95% w/w of α

-lactalbumin.

10. The liquid nutritional formulation of claim 8, wherein the emulsifier comprises at least about 98% w/w of α

-lactalbumin.

11. The liquid nutritional formulation of claim 8, further comprising at least one prebiotic.

12. The liquid nutritional formulation of claim 8, further comprising vitamins and minerals.

13. The liquid nutritional formulation of claim 8, further comprising at least one ω

-6 fatty acid.

14. The liquid nutritional formulation of claim 8, further comprising arachidonic acid.

15. A method for providing nutritional support to a preterm infant, wherein the method comprises enterally administering to the preterm infant a nutritional formulation comprising:

an emulsion comprising docosahexaenoic acid, wherein the emulsion is dispersed in an aqueous component comprising arachidonic acid and at least one of an amino acid component selected from the group consisting of;

arginine, arginyl-glutamine, and alanyl-glutamine; and

an emulsifier comprising at least about 95% w/w α

-lactalbumin.

16. The liquid nutritional formulation of claim 15, wherein the emulsifier comprises at least about 98% w/w of α

-lactalbumin.

17. The liquid nutritional formulation of claim 15, further comprising at least one prebiotic.

18. The liquid nutritional formulation of claim 15, further comprising vitamins and minerals.

19. The liquid nutritional formulation of claim 15, further comprising alanyl glutamine dipeptide.

20. The liquid nutritional formulation of claim 15, further comprising arginyl glutamine dipeptide.