Methods and Systems for Imaging and Modeling Skin Using Polarized Lighting

• US 20110211047A1
• Filed: 04/01/2011
• Published: 09/01/2011
• Est. Priority Date: 03/27/2009
• Status: Active Grant

• Current Assignee: BrighTex Bio-Photonics LLC
• Original Assignee: BrighTex Bio-Photonics LLC
• Inventors: Sharma, Shefali, Chhibbar, Ashutosh, Chhibber, Rajeshwar
• Granted Patent: US 8,823,934 B2
• Time in Patent Office: Days
• US Class Current: 348/47
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: G06T 2207/30088 Skin; Dermal
• CPC Class Codes: G06T 7/0014 using an image reference approach
• CPC Class Codes: H04N 13/211 using temporal multiplexing
• CPC Class Codes: H04N 13/243 using three or more 2D image sensors
• CPC Class Codes: H04N 13/254 in combination with electromagnetic radiation sources for illuminating objects
• CPC Class Codes: H04N 23/55 Optical parts specially adapted for electronic image sensors; Mounting thereof
• CPC Class Codes: H04N 23/56 provided with illuminating means

Abstract

A method for imaging skin includes illuminating a subject with at least one light source of one or more light sources. The method includes acquiring a first image of the subject in a first polarization with a respective photodetector of one or more photodetectors configured to acquire images of the subject as illuminated by the at least one light source, and acquiring a second image of the subject in a second polarization with the respective photodetector. The method also includes generating a subtraction image by subtracting at least a portion of the first image from a corresponding portion of the second image, and providing at least a portion of the subtraction image for display.

Claims

1. An imaging system for imaging skin, comprising:

one or more light sources configured to illuminate a subject;

one or more photodetectors configured to acquire images of the subject as illuminated by at least one of the one or more light sources;

one or more adjustable polarizers, each coupled with a respective photodetector of the one or more photodetectors and configured to provide an adjustable axis of polarization of light received by the respective photodetector;

one or more processors; and

memory storing one or more programs for execution by the one or more processors, the one or more programs including instructions for;

acquiring a first image of the subject in a first polarization with the respective photodetector;

acquiring a second image of the subject in a second polarization with the respective photodetector;

generating a subtraction image by subtracting at least a portion of the first image from a corresponding portion of the second image; and

providing at least a portion of the subtraction image for display.

2. The system of claim 1, wherein the one or more light sources include at least one polarizer to polarize light provided by at least one of the one or more light sources to illuminate the subject.

3. The system of claim 1, wherein:

the subject is illuminated with light polarized in the first polarization;

the first image of the subject in the first polarization is acquired with the respective photodetector while a respective adjustable polarizer coupled with the respective photodetector is configured to provide a first axis of polarization such that the respective adjustable polarizer transmits the light polarized in the first polarization; and

the second image of the subject in the second polarization is acquired with the respective photodetector while the respective adjustable polarizer coupled with the respective photodetector is configured to provide a second axis of polarization distinct from the first axis of polarization such that the respective adjustable polarizer rejects the light polarized in the first polarization.

4. The system of claim 1, wherein:

the subject is illuminated with light polarized in the first polarization;

the first image of the subject in the first polarization is acquired with the respective photodetector while a respective adjustable polarizer coupled with the respective photodetector is configured to provide a first axis of polarization such that the respective adjustable polarizer rejects the light polarized in the first polarization; and

the second image of the subject in the second polarization is acquired with the respective photodetector while the respective adjustable polarizer coupled with the respective photodetector is configured to provide a second axis of polarization distinct from the first axis of polarization such that the respective adjustable polarizer transmits the light polarized in the first polarization.

5. The system of claim 1, wherein:

at least one of the one or more light sources is configured to illuminate the subject with one or more image patterns;

the system includes a first photodetector and a second photodetector to acquire images of the subject, wherein the first photodetector and the second photodetector are positioned at distinct locations; and

the one or more programs include instructions for;

acquiring with the first photodetector a third image of the subject illuminated with a respective image pattern of the one or more image patterns;

acquiring with the second photodetector a fourth image of the subject illuminated with the respective image pattern of the one or more image patterns;

generating a three-dimensional model corresponding to at least a portion of the subject by comparing at least a portion of the third image and at least a portion of the fourth image; and

mapping at least a portion of the subtraction image onto the three-dimensional model.

6. The system of claim 5, wherein:

the respective image pattern includes a plurality of visual elements; and

the instructions for generating the three-dimensional model include determining three-dimensional positions of respective visual elements of the plurality of visual elements, wherein each position of a respective visual element is determined at least by comparing a first location of the respective visual element in the third image and a second location of the respective visual element in the fourth image.

7. The system of claim 5, further comprising a filter to filter out red light, wherein

the one or more programs include instructions for:

illuminating the subject with polarized light, the polarized light including at least a portion of light from at least one of the one or more light sources;

acquiring a filtered image, wherein the red light is filtered out by the filter; and

mapping at least a portion of the filtered image onto the three-dimensional model.

8. The system of claim 5, wherein the at least one of the one or more light sources configured to illuminate the subject with one or more image patterns is positioned between the first photodetector and the second photodetector.

9. The system of claim 1, wherein

a first light source and a second light source configured to illuminate the subject with one or more image patterns;

the system includes a first photodetector, a second photodetector, and a third photodetector to acquire images of the subject, wherein the first photodetector, the second photodetector, and the third photodetector are positioned at distinct locations; and

the one or more programs include instructions for;

acquiring with the first photodetector a third image of the subject illuminated with a first image pattern of the one or more image patterns from the first light source;

acquiring with the second photodetector a fourth image of the subject illuminated with the first image pattern of the one or more image patterns from the first light source;

acquiring with the second photodetector a fifth image of the subject illuminated with a second image pattern of the one or more image patterns from the second light source;

acquiring with the third photodetector a sixth image of the subject illuminated with the second image pattern of the one or more image patterns from the second light source;

generating a three-dimensional model corresponding to at least a portion of the subject by comparing at least a portion of the third image and at least a portion of the fourth image, and comparing at least a portion of the fifth image and at least a portion of the sixth image; and

mapping at least a portion of the subtraction image onto the three-dimensional model.

10. The system of claim 9, wherein the first image pattern and the second image pattern are identical.

11. A method for imaging skin, performed by a system including one or more processors and memory storing one or more programs for execution by the one or more processors, the method comprising:

illuminating a subject with at least one light source of one or more light sources;

acquiring a first image of the subject in a first polarization with a respective photodetector of one or more photodetectors configured to acquire images of the subject as illuminated by the at least one light source;

acquiring a second image of the subject in a second polarization with the respective photodetector;

generating a subtraction image by subtracting at least a portion of the first image from a corresponding portion of the second image; and

providing at least a portion of the subtraction image for display.

12. The method of claim 11, wherein the one or more light sources include at least one polarizer to polarize light provided by at least one of the one or more light sources to illuminate the subject.

13. The method of claim 11, wherein;

the subject is illuminated with light polarized in the first polarization;

the first image of the subject in the first polarization is acquired with the respective photodetector while a respective adjustable polarizer coupled with the respective photodetector is configured to provide a first axis of polarization such that the respective adjustable polarizer transmits the light polarized in the first polarization; and

the second image of the subject in the second polarization is acquired with the respective photodetector while the respective adjustable polarizer coupled with the respective photodetector is configured to provide a second axis of polarization distinct from the first axis of polarization such that the respective adjustable polarizer rejects the light polarized in the first polarization.

14. The method of claim 11, wherein:

the subject is illuminated with light polarized in the first polarization;

the first image of the subject in the first polarization is acquired with the respective photodetector while a respective adjustable polarizer coupled with the respective photodetector is configured to provide a first axis of polarization such that the respective adjustable polarizer rejects the light polarized in the first polarization; and

the second image of the subject in the second polarization is acquired with the respective photodetector while the respective adjustable polarizer coupled with the respective photodetector is configured to provide a second axis of polarization distinct from the first axis of polarization such that the respective adjustable polarizer transmits the light polarized in the first polarization.

15. The method of claim 11, further comprising:

acquiring with a first photodetector a third image of the subject illuminated with a respective image pattern of one or more image patterns;

acquiring with a second photodetector a fourth image of the subject illuminated with the respective image pattern of the one or more image patterns, wherein the first photodetector and the second photodetector are positioned at distinct locations;

generating a three-dimensional model corresponding to at least a portion of the subject by comparing at least a portion of the third image and at least a portion of the fourth image; and

mapping at least a portion of the subtraction image onto the three-dimensional model.

16. The method of claim 15, wherein:

the respective image pattern includes a plurality of visual elements; and

generating the three-dimensional model includes determining three-dimensional positions of respective visual elements of the plurality of visual elements, wherein each position of a respective visual element is determined at least by comparing a first location of the respective visual element in the third image and a second location of the respective visual element in the fourth image.

17. The method of claim 15, further comprising:

illuminating the subject with polarized light, the polarized light including at least a portion of light from at least one of the one or more light sources;

acquiring a filtered image, wherein the red light is filtered out by a filter; and

mapping at least a portion of the filtered image onto the three-dimensional model.

18. The method of claim 15, including illuminating the subject with the respective image pattern using at least one of the one or more light sources positioned between the first photodetector and the second photodetector.

19. The method of claim 11, wherein

acquiring with a first photodetector a third image of the subject illuminated with a first image pattern of one or more image patterns from a first light source;

acquiring with a second photodetector a fourth image of the subject illuminated with the first image pattern of the one or more image patterns from the first light source;

acquiring with the second photodetector a fifth image of the subject illuminated with a second image pattern of the one or more image patterns from the second light source;

acquiring with a third photodetector a sixth image of the subject illuminated with the second image pattern of the one or more image patterns from the second light source;

generating a three-dimensional model corresponding to at least a portion of the subject by comparing at least a portion of the third image and at least a portion of the fourth image, and comparing at least a portion of the fifth image and at least a portion of the sixth image; and

mapping at least a portion of the subtraction image onto the three-dimensional model.

20. The method of claim 19, wherein the first image pattern and the second image pattern are identical.