RADIATIVE HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS

• US 20110212027A1
• Filed: 07/23/2009
• Published: 09/01/2011
• Est. Priority Date: 07/24/2008
• Status: Abandoned Application

• Current Assignee: Children's Medical Center Corporation, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Children's Medical Center Corporation, General Hospital Corporation, Massachusetts Institute of Technology
• Inventors: Neeley, William L., Hoare, Todd R., Fenn, Alan J., Langer, Robert S., Kohane, Daniel S.
• Application Number:
  US13/055,227
• Publication Number:
  US 20110212027A1
• Time in Patent Office: Days
• US Class Current: 424/9.1
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/0002 Galenical forms characterised by the drug release technique; Application systems commanded by energy
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: C08G 73/0266 Polyanilines or derivatives thereof
• CPC Class Codes: C08L 79/02 Polyamines

Abstract

The present invention generally relates to systems and methods for releasing a releasable species from an article using an external trigger, for example, using microwave radiation or other forms of radiation, e.g., radiofrequency radiation. Such systems and methods may be useful, for example, in biological applications (e.g., as an implant within a subject), industrial applications, commercial applications, or the like. One aspect of the invention is generally directed to an article containing a radiation-sensitive polymer or other radiation-sensitive material. Exposure of the radiation- sensitive material to radiation such as microwave and/or radiofrequency radiation may cause the material to increase in temperature. This increase in temperature may be used, in some cases, to cause the release of a drug or other releasable species from the article. For instance, a drug may be contained in a heat-sensitive material positioned in thermal communication with the radiation-sensitive material, or a drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material positioned in thermal communication with the radiation-sensitive material. In another aspect of the invention, a receive antenna, such as a microwave receive antenna may be used to focus microwave and/or radiofrequency radiation on an article. For instance, the receive antenna may focus microwave and/or radiofrequency radiation on a radiation-sensitive material in the article. Such focusing may be useful, in some embodiments, to control release of a drug or other releasable species from the article. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, and the like.

Claims

1. An article comprising a radiation-sensitive polymer and a releasable species releasable upon application of microwave radiation and/or radiofrequency radiation to at least a portion of the radiation-sensitive polymer.

2. The article of claim 1, wherein the radiation-sensitive polymer comprises a conjugated polymer.

7. The article of claim 1, wherein the radiation-sensitive polymer is a microwave-sensitive polymer.

8. The article of claim 7, wherein the microwave-sensitive polymer can be heated by at least about 0.5°

C., in the absence of water, by directing microwave radiation at the microwave-sensitive polymer having a transmit power level of no more than about 10 kW and a frequency of between about 0.3 GHz and about 300 GHz.

9. The article of claim 1, wherein the radiation-sensitive polymer is a radiofrequency-sensitive polymer.

10. The article of claim 1, wherein the article is implantable.

11. The article of claim 1, wherein the article at least partially defines an enclosure containing the releasable species.

12. The article of claim 11, wherein the enclosure contains an aqueous solution containing the releasable species.

15. The article of claim 11, wherein the enclosure is isolated, at least in part, by a heat-sensitive material in thermal communication with the radiation-sensitive polymer.

16. The article of claim 15, wherein the heat-sensitive material comprises a gel.

22. The article of claim 1, wherein the article further comprises a heat-sensitive material in thermal communication with the radiation-sensitive polymer.

23. The article of claim 1, wherein the article exhibits an increase of at least about 10% in the release of releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of the microwave radiation and/or the radiofrequency radiation.

24. The article of claim 1, wherein heating the radiation-sensitive polymer by at least about 0.5°

C. causes the article to exhibit an increase of at least about 10% in the release of the releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of heating.

25. The article of claim 1, wherein the article further contains a receive antenna.

3-6. -6. (canceled)

13-14. -14. (canceled)

17-21. -21. (canceled)

26-34. -34. (canceled)

35. An article comprising a radiation-sensitive material and a releasable species, wherein, when the radiation-sensitive material is heated by at least about 0.5°

C., release of the releasable species from the article increases by at least about 10%, relative to the amount of release of the releasable species from the article in the absence of heating of the radiation-sensitive material.

36-48. -48. (canceled)

49. An article comprising a receive antenna, configured for focusing microwave radiation and/or radiofrequency radiation on a radiation-sensitive material, the radiation-sensitive material being in thermal communication with a heat-sensitive material.

61. The article of claim 49, wherein the receive antenna comprises a metal.

62. The article of claim 49, wherein the receive antenna comprises a material having a conductivity of at least about 10⁷ S m⁻

1.

68. The article of claim 49, wherein the receive antenna is present on at least a portion of the surface of the article.

71. The article of claim 49, wherein at least a portion of the receive antenna defines a dipole surrounding at least a portion of the article.

50-60. -60. (canceled)

63-67. -67. (canceled)

69-70. -70. (canceled)

72-118. -118. (canceled)