Nucleic Acid Ligand Complexes
First Claim
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1. A method for imaging a site expressing a Target in a patient, the method comprising:
- covalently linking a Nucleic Acid Ligand with magnetite, wherein said Nucleic Acid Ligand has a specific binding affinity for said Target;
administering said Nucleic Acid Ligand associated with magnetite to a patient; and
performing nuclear magnetic resonance (NMR) imaging.
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Abstract
This invention discloses a method for preparing a therapeutic or diagnostic complex comprised of a nucleic acid ligand and a lipophilic compound or non-immunogenic, high molecular weight compound by identifying a nucleic acid ligand by SELEX methodology and associating the nucleic acid ligand with a lipophilic compound or a non-immunogenic, high molecular weight compound. The invention further discloses complexes comprising one or more nucleic acid ligands in association with a lipophilic compound or non-immunogenic, high molecular weight compound.
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Citations
1 Claim
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1. A method for imaging a site expressing a Target in a patient, the method comprising:
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covalently linking a Nucleic Acid Ligand with magnetite, wherein said Nucleic Acid Ligand has a specific binding affinity for said Target; administering said Nucleic Acid Ligand associated with magnetite to a patient; and performing nuclear magnetic resonance (NMR) imaging.
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Specification