MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS

• US 20110212163A1
• Filed: 07/23/2009
• Published: 09/01/2011
• Est. Priority Date: 07/24/2008
• Status: Abandoned Application

• Current Assignee: Children's Medical Center Corporation, Massachusetts Institute of Technology, The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Children's Medical Center Corporation, General Hospital Corporation, Massachusetts Institute of Technology
• Inventors: Kim, Grace Y., Khushrushahi, Shahriar R., Yeo, Yoon, Langer, Robert S., Shapiro, Mikhail G., Kohane, Daniel S., Hoare, Todd R.
• Application Number:
  US13/055,195
• Publication Number:
  US 20110212163A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 41/00 Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.

Claims

1. An article containing a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes at least some release of the releasable species externally from the enclosure.

2. The article of claim 1, wherein the magnetically-susceptible material comprises iron.

3. The article of claim 1, wherein the article is implantable.

4. The article of claim 1, wherein the releasable species is contained in the magnetically-susceptible material.

5. The article of claim 1, wherein the article defines an enclosure containing the releasable species.

6. The article of claim 5, wherein the enclosure contains an aqueous solution containing the releasable species.

7. The article of claim 5, wherein the enclosure contains an organic solution containing the releasable species.

8. The article of claim 5, wherein the enclosure contains a solid containing the releasable species.

9. The article of claim 5, wherein the enclosure contains a gel containing the releasable species.

10. The article of claim 5, wherein the enclosure contains a liquid containing the releasable species.

11. The article of claim 1, wherein the releasable species is solid.

13. The article of claim 1, wherein the article further comprises a heat-sensitive material in thermal communication with the magnetically-susceptible material.

14. The article of claim 13, wherein the heat-sensitive material comprises a poly(N-alkyacrylamide).

17. The article of claim 1, wherein the article exhibits an increase of at least about 10% in the release of releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of the oscillating magnetic field.

18. The article of claim 1, wherein heating the magnetically-susceptible material by at least about 0.5°

C. causes the article to exhibit an increase of at least about 10% in the release of the releasable species from the article, relative to the amount of release of the releasable species from the article in the absence of heating.

19. The article of claim 1, wherein the releasable species comprises a drug.

20. The article of claim 1, wherein the enclosure is a particle.

21. The article of claim 1, wherein the enclosure is a liposome.

12. (canceled)

15-16. -16. (canceled)

22. An article containing a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes an increase of release of the releasable species of at least about 10% from the implantable article, relative to the amount of release of the releasable species from the article in the absence of oscillating magnetic field.

23-25. -25. (canceled)

26. An article comprising a magnetically-susceptible material at least partially defining an enclosure containing a releasable species, the magnetically-susceptible material being in thermal communication with a heat-sensitive material, wherein application of an oscillating magnetic field to the magnetically-susceptible material causes the heat-sensitive material to increase in temperature by at least about 0.5°

C.

27-64. -64. (canceled)