Quinolone Neuropeptide S Receptor Antagonists

• US 20110212946A1
• Filed: 11/03/2009
• Published: 09/01/2011
• Est. Priority Date: 11/13/2008
• Status: Active Grant

• Current Assignee: Merck Sharp & Dohme LLC (Merck & Co., Inc.)
• Original Assignee: Merck Sharp & Dohme Corporation (Merck & Co., Inc.)
• Inventors: Bilodeau, Mark T., Manley, Peter J., Li, Yiwei, Zartman, Amy, Melamed, Jeffrey, Hartnett, John C., Kett, Nathan R., Trotter, B. Wesley, Barrow, James C., Shipe, William D., Cox, Christopher D.
• Granted Patent: US 8,389,720 B2
• Time in Patent Office: Days
• US Class Current: 514/217.07
• CPC Class Codes: A61K 31/47 Quinolines; Isoquinolines
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: C07D 401/12 linked by a chain containing hetero atoms as chain links
• CPC Class Codes: C07D 405/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention is directed to quinolone compounds which are antagonists of neuropeptide S receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which the neuropeptide S receptor is involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the neuropeptide S receptor is involved.

Claims

1. A compound of the formula I:

2. The compound of claim 1 wherein R¹ is hydrogen or methyl.

3. The compound of claim 2 wherein R¹ is methyl.

4. The compound of claim 1 wherein R² is selected from the group consisting of:

(1) tetralone,

(2) —

CH₂-cyclohexyl, where the cyclohexyl is unsubstituted or substituted with one or more substituents selected from R¹³,

(3) —

CH₂-morpholinyl, where the morpholinyl is unsubstituted or substituted with one or more substituents selected from R¹³, and

(4) —

CH₂—

CH-(phenyl)heterocycle, where the heterocycle is unsubstituted or substituted with one or more substituents selected from R¹³.

5. The compound of claim 1 wherein R³ is selected from the group consisting of:

(1) —

C_1-6alkyl, where the alkyl is unsubstituted or substituted with one or more substituents selected from —

C_3-6cycloalkyl and phenyl, where the cycloalkyl and phenyl are independently unsubstituted or substituted with one or more substituents selected from the group consisting of;

(a) halogen,

(b) hydroxyl,

(c) C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl or napthyl, and

(d) —

O—

C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl;

(2) —

C_3-6cycloalkyl, where the cycloalkyl is unsubstituted or substituted with one or more substituents selected from —

C_1-6alkyl and phenyl, where the alkyl and phenyl are independently unsubstituted or substituted with one or more substituents selected from the group consisting of;

(a) halogen,

(b) hydroxyl,

(c) C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl or napthyl, and

(d) —

O—

C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl;

(3) -phenyl, which is unsubstituted or substituted with one or more substituents selected from the group consisting of;

(a) halogen,

(b) hydroxyl,

(c) C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl or napthyl, and

(d) —

O—

C_1-6alkyl, which is unsubstituted or substituted with halogen, hydroxyl or phenyl.

6. The compound of claim 5 wherein R³ is selected from the group consisting of:

cyclohexyl, cyclopentyl, sec-butyl, neo-pentyl and phenyl.

7. The compound of claim 6 wherein R³ is cyclohexyl.

9. A pharmaceutical composition which comprises an inert carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

12. A method for enhancing the quality of sleep in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

13. A method for treating insomnia in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

14. A method for treating or controlling anxiety in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

15. A method for treating or controlling depression in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

16. A method for treating or controlling inflammatory bowel disease in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

17. A method for treating or controlling obesity in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of the compound of claim 1 or a pharmaceutically acceptable salt thereof.

8. A compound which is selected from the group consisting of:

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)oxepan-3-yl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[4-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl}cyclohexanecarboxamide;

N-({4-[4-(1-methylethyl)piperazin-1-yl]tetrahydro-2H-pyran-4-yl}methyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[4-(4-phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl}cyclohexanecarboxamide;

N-{[4-(4-benzylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl]methyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-({4-[4-(2-hydroxyethyl)piperazin-1-yl]tetrahydro-2H-pyran-4-yl}methyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(4-piperazin-1-yltetrahydro-2H-pyran-4-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-({4-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]tetrahydro-2H-pyran-4-yl}methyl)cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

4-hydroxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-N˜

2˜

(2,2,2-trifluoroethyl)-L-valinamide

N-[3-methoxy-2-methyl-2-(4-methylpiperazin-1-yl)propyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(3-piperazin-1-yltetrahydro-2H-pyran-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cycloheptanecarboxamide;

2-ethyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}butanamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-2-propylpentanamide

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclopentanecarboxamide;

2-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}acetamide

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydrofuran-3-yl]methyl}cyclohexanecarboxamide;

N-{[3-(4-methyl-1,4-diazepan-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(2-phenylpiperidin-1-yl)ethyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(2-phenylpyrrolidin-1-yl)ethyl]cyclohexanecarboxamide;

N-{2-[benzyl(methyl)amino]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-5-phenyl-1,2-dihydropyridin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

(1S,4R)—

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}bicyclo[2.2.1]heptane-2-carboxamide;

3-methoxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-4-(trifluoromethyl)cyclohexanecarboxamide;

2-methyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

4-(1-methylethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

4-tert-butyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

2-cyclohexyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}acetamide

4-methyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}pentanamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}benzamide

3-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}propanamide

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}-2-phenylacetamide

2-cycloheptyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}acetamide

3,3-difluoro-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclopentanecarboxamide;

4,4-difluoro-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[3-(4-methylpiperazin-1-yl)tetrahydro-2H-pyran-3-yl]methyl}cyclohexanecarboxamide;

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-benzothiophene-2-carboxamide;

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-3-phenylpropanamide;

(1R,2R,4R)—

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]bicyclo[2.2.1]hept-5-ene-2-carboxamide;

(1S,2S)—

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-2-phenylcyclopropanecarboxamide;

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclopropanecarboxamide;

3-methyl-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]butanamide;

3-cyclopentyl-1-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]urea;

N-[(1-morpholin-4-ylcyclohexyl)methyl]-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-piperidin-1-ylcyclohexyl)methyl]cyclohexanecarboxamide;

N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclobutyl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl}cyclohexanecarboxamide;

(1R,2R,4R)—

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl}bicyclo[2.2.1]hept-5-ene-2-carboxamide;

2-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclopentyl]methyl}acetamide;

2-(1-hydroxycyclopentyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}acetamide;

cis-4-hydroxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

4-(hydroxymethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

cis-4-(hydroxymethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

trans-4-(hydroxymethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

N-{[1-(2-methoxyethyl)-2-oxo-1,2-dihydroquinolin-3-yl]methyl}-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-morpholin-4-ylcycloheptyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-morpholin-4-ylcyclopentyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-piperidin-1-ylcyclohexyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-morpholin-4-ylcyclohexyl)methyl]cyclohexanecarboxamide;

cis-4-hydroxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-piperidin-1-ylcyclohexyl)methyl]cyclohexanecarboxamide;

cis-4-hydroxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-morpholin-4-ylcyclohexyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1-morpholin-4-ylcycloheptyl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{[1-(4-methylpiperazin-1-yl)cyclohexyl]methyl}cyclohexanecarboxamide;

N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)benzamide;

3-methyl-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)butanamide;

3-tert-butyl-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-phenyl-2-piperidin-1-ylethyl)urea

2-methyl-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;

N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-2-phenyl-N-(2-phenyl-2-piperidin-1-ylethyl)acetamide;

N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide;

N-[1-(2-methylphenyl)piperidin-4-yl]-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

3-methyl-N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)butanamide;

N-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)thiophene-2-carboxamide;

3-(2-chlorophenyl)-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(1,2,3,4-tetrahydronaphthalen-1-yl)urea;

3-(2-methoxyphenyl)-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(1,2,3,4-tetrahydronaphthalen-1-yl)urea;

3-cyclopentyl-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-phenyl-2-piperidin-1-ylethyl)urea;

3-cyclohexyl-1-[(2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-phenyl-2-piperidin-1-ylethyl)urea;

2-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(4-methylpiperazin-1-yl)-2-phenylethyl]acetamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(4-methylpiperazin-1-yl)-2-phenylethyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)cyclohexanecarboxamide;

2-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(4-methylpiperazin-1-yl)ethyl]acetamide;

2-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)acetamide;

cis-4-(hydroxymethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)cyclohexanecarboxamide;

2-(1-hydroxycyclopentyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)acetamide;

cis-4-hydroxy-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)cyclohexanecarboxamide;

N-(1-benzylpiperidin-3-yl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-{4-[2-(4-methylphenyl)ethyl]piperidin-1-yl}ethyl)cyclohexanecarboxamide;

N-[2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(2,3-dihydro-1H-indol-1-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(4-benzylpiperazin-1-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(4-benzylpiperazin-1-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[3-(2-methylphenyl)pyrrolidin-1-yl]ethyl}cyclohexanecarboxamide;

N-{2-[2-(1H-indol-2-yl)piperidin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

1-tert-butyl-2-methyl-(2S,4S)-4-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyrrolidine-1,2-dicarboxylate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(2-phenyl-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)ethyl]cyclohexanecarboxamide;

benzyl-3-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-phenylpiperidine-1-carboxylate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-piperidin-1-yl-2-pyridin-3-ylethyl)cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[2-(phenoxymethyl)morpholin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(4-methylpiperazin-1-yl)ethyl]cyclohexanecarboxamide;

N-[(3R)-1-(1-methylethyl)pyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(dimethylamino)-1-methylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

benzyl-{2-[(tert-butoxycarbonyl)amino]ethyl}(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}ethyl)carbamate;

N-{2-[4-(2,3-dihydro-1H-inden-2-yl)piperazin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

tert-butyl-[(3R,4R)-1-benzyl-4-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}pyrrolidin-3-yl]carbamate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl}cyclohexanecarboxamide;

N-{2-[3-(1,3-benzoxazol-2-yl)piperidin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(4-benzylpiperazin-1-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(2S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1S,2R)-2-phenylcyclopentyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(3R,4R)-1-methyl-3-phenylpiperidin-4-yl]cyclohexanecarboxamide;

N-[2-(3,3-dimethylpiperidin-2-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1S,2S)-2-phenylcyclopentyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenylcyclopentyl)cyclohexanecarboxamide;

N-[3-(diethylamino)-1,1-dimethylpropyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(1S,9aR)-octahydro-2H-quinolizin-1-ylmethyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(1-methyl-3-pyrrolidin-1-ylpropyl)cyclohexanecarboxamide;

N-(1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1,1-dimethyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1,1-dimethyl-3-pyrrolidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-(3-phenylpyrrolidin-1-yl)ethyl]cyclohexanecarboxamide;

N-[2-(dimethylamino)-2-pyridin-2-ylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[4-(1-pyrrolidin-1-ylethyl)piperidin-1-yl]ethyl}cyclohexanecarboxamide;

tert-butyl-{[1-(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}ethyl)piperidin-3-yl]methyl}carbamate

tert-butyl-1-({(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}methyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;

N-[(3R)-1-(1-methylethyl)pyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{[1-(1-methylethyl)pyrrolidin-2-yl]methyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{[1-(1-methylethyl)pyrrolidin-2-yl]methyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(3S)-1-benzylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-piperazin-1-ylethyl)cyclohexanecarboxamide;

N-[(3R)-1-benzylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1,1-dimethyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

tert-butyl-4-(3-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-3-methylbutyl)piperazine-1-carboxylate;

tert-butyl-4-(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}ethyl)piperidine-1-carboxylate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-piperidin-4-ylethyl)cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-(4,4-difluoro-piperidin-1-yl)propyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]tetrahydro-2H-pyran-4-carboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-4,4-difluoro-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]tetrahydro-2H-pyran-3-carboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]tetrahydro-2H-pyran-2-carboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-2-(tetrahydrofuran-3-yl)acetamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-2-(1-hydroxycyclopentyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]acetamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-piperidin-1-ylpropyl)-N-[(1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-ethyl-1-methyl-3-morpholin-4-ylpropyl)-N-[(1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[2-phenylpiperazin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-(cyclopropylmethyl)-2-phenylpiperazin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-(cyclopropylcarbonyl)-2-phenylpiperazin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-(cyclobutylmethyl)-2-phenylpiperazin-1-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(4-benzyl-2-phenylpiperazin-1-yl)ethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethyl]cyclohexanecarboxamide;

N-[2-(4-hydroxytetrahydro-2H-pyran-4-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-phenyl-2-(tetrahydro-2H-pyran-4-yl)ethyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[2-phenyl-2-(tetrahydro-2H-pyran-3-yl)ethyl]cyclohexanecarboxamide;

4-(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-1-phenylethyl)-1-(2,2-dimethylpropyl)piperidine;

N-[2-(4-hydroxy-1-methylpiperidin-4-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

tert-butyl-4-(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-1-phenylethyl)-4-hydroxypiperidine-1-carboxylate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-4-ylethyl)cyclohexanecarboxamide;

N-[2-(4-hydroxypiperidin-4-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(2-hydroxyethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-hydroxy-1-(2-hydroxyethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[1-(1,3-oxazol-5-ylmethyl)piperidin-4-yl]-2-phenylethyl}cyclohexanecarboxamide;

N-{2-[1-(2,3-dihydroxypropyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

[4-(2-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-1-phenylethyl)piperidin-1-yl]acetic acid;

N-{2-[1-(cyclopropylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(2,2-dimethylpropyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(cyclopentylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[1-(2-methylpropyl)piperidin-4-yl]-2-phenylethyl}cyclohexanecarboxamide;

N-[2-(1-butylpiperidin-4-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(3-methylbutyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[1-(1,3-oxazol-2-ylmethyl)piperidin-4-yl]-2-phenylethyl}cyclohexanecarboxamide;

N-[2-(1-benzylpiperidin-4-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(pyridin-2-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(pyridin-3-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(pyridin-4-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-(2-{1-[(1-methyl-1H-imidazol-2-yl)methyl]piperidin-4-yl}-2-phenylethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(1,3-thiazol-4-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[1-(1,3-oxazol-4-ylmethyl)piperidin-4-yl]-2-phenylethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(1H-pyrazol-4-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(1H-pyrazol-5-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-phenyl-2-[1-(1H-1,2,3-triazol-4-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-{2-[1-(cyclopropylmethyl)piperidin-4-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-{2-[1-(1H-pyrazol-4-ylmethyl)piperidin-4-yl]ethyl}cyclohexanecarboxamide;

N-{2-[1-(1H-imidazol-2-ylmethyl)piperidin-4-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(2,2-dimethylpropyl)piperidin-4-yl]ethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(cyclopropylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(cyclopropylmethyl)-4-hydroxypiperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-hydroxy-1-(1H-pyrazol-4-ylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[4-hydroxy-1-(1H-imidazol-2-ylmethyl)piperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-{2-[1-(2,2-dimethylpropyl)-4-hydroxypiperidin-4-yl]-2-phenylethyl}-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[1-(cyclobutylmethyl)-3-methylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-benzyl-3-methylpyrrolidin-3-yl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

tert-butyl-4-{(cyclohexylcarbonyl)[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}piperidine-1-carboxylate;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-piperidin-4-ylcyclohexanecarboxamide;

N-[1-(cyclopropylmethyl)piperidin-4-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[1-(cyclobutylmethyl)piperidin-4-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(1-methylpiperidin-4-yl)cyclohexanecarboxamide;

N-[1-(cyclopropylcarbonyl)piperidin-4-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[1-(cyclobutylmethyl)-3-methylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(3R)-pyrrolidin-3-yl]cyclohexanecarboxamide;

N-(1,1-dimethyl-2-piperidin-1-ylethyl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-(1-benzylpiperidin-4-yl)-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-[(3R)-1-methylpyrrolidin-3-yl]cyclohexanecarboxamide;

N-[(3R)-1-ethylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(3R)-1-(cyclopropylmethyl)pyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-cyclopentyl-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(3R)-1-acetylpyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(3R)-1-(cyclopropylcarbonyl)pyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(3R)-1-(cyclobutylmethyl)pyrrolidin-3-yl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[2-(4,4-difluoropiperidin-1-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2,5,6,7,8-hexahydroquinolin-3-yl)methyl]-N-(2-phenyl-2-piperidin-1-ylethyl)cyclohexanecarboxamide;

N-[2-(4,4-difluoropiperidin-1-yl)-2-phenylethyl]-N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]cyclohexanecarboxamide;

N-[(1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-N-(2-morpholin-4-yl-2-phenylethyl)cyclohexanecarboxamide;

or a pharmaceutically acceptable salt thereof.

10. (canceled)

11. (canceled)