MOVEMENT MONITORING SYSTEM AND APPARATUS FOR OBJECTIVE ASSESSMENT OF MOVEMENT DISORDERS

• US 20110213278A1
• Filed: 02/28/2011
• Published: 09/01/2011
• Est. Priority Date: 02/26/2010
• Status: Abandoned Application

• Current Assignee: APDM, Inc., Oregon Health & Science University
• Original Assignee: APDM, Inc., Oregon Health & Science University
• Inventors: Brandon, Timothy, Gallino, Gavin, Pearson, Sean, Holmstrom, Lars, Riobo Aboy, Pedro Mateo, McNames, James, Greenberg, Andrew, Horak, Fay
• Application Number:
  US13/037,305
• Publication Number:
  US 20110213278A1
• Time in Patent Office: Days
• US Class Current: 600/595
• CPC Class Codes: A61B 2560/0214 of power generation or supply
• CPC Class Codes: A61B 2560/0242 adapted to measure environmental factors, e.g. temperature, pollution
• CPC Class Codes: A61B 2560/0456 Apparatus provided with a docking unit
• CPC Class Codes: A61B 2560/0475 Special features of memory means, e.g. removable memory cards
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/0223 Magnetic field sensors
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/1101 Detecting tremor
• CPC Class Codes: A61B 5/1111 Detecting tooth mobility
• CPC Class Codes: A61B 5/112 Gait analysis
• CPC Class Codes: A61B 5/4023 Evaluating sense of balance
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/6823 Trunk, e.g., chest, back, abdomen, hip

Abstract

Disclosed embodiments include a movement monitoring system and apparatus for objective assessment of movement disorders of a subject, comprising (a) one or more movement monitors, and (b) a computer-implemented analysis system comprising one or more protocols and associated data analysis methods to objectively quantify movement disorders based on movement data acquired by the movement monitors. According to one embodiment, the movement monitors are robust wireless synchronized movement monitors and the protocols include one or more tests for assessment of neural control of balance.

Claims

1. A movement monitoring system and apparatus for objective assessment of movement disorders of a subject, comprising:

(a) one or more movement monitors; and

(b) a computer-implemented analysis system comprising one or more protocols and associated data analysis methods to objectively quantify one or more movement disorders of said subject based on a plurality of movement data acquired by said movement monitors from said subject.

2. The movement monitoring system and apparatus of claim 1, wherein said one or more movement monitors are wireless synchronized movement monitors.

3. The movement monitoring system and apparatus of claim 2, wherein said protocols include one or more tests for assessment of neural control of balance.

4. The movement monitoring system and apparatus of claim 3, wherein said tests for assessment of neural control of balance are an instrumented TUG test, an instrumented Sway test, an instrumented STEP test, an instrumented PUSH test, or a combination thereof.

5. The movement monitoring system and apparatus of claim 4, wherein said analysis system further comprises:

(a) a data management database;

(b) one or more analysis methods to generate one or more outcome metrics or a combined summary score from said tests; and

(c) a graphical user interface.

6. The movement monitoring system and apparatus of claim 5, wherein said graphical user interface comprises:

(a) an operator graphical user interface comprising a control interface, a configuration interface, a data management interface, and a data visualization interface; and

(b) a subject graphical user interface.

7. The movement monitoring system and apparatus of claim 6, wherein said subject graphical user interface comprises:

(a) a training module to train said subject to perform said protocols; and

(b) a feedback system to provide auditory and/or visual feedback to said subject during performance of said protocols.

8. The movement monitoring system and apparatus of claim 7, wherein said operator graphical user interface further comprises a remote control for remote control operation.

9. The movement monitoring system and apparatus of claim 8, wherein said analysis system further includes a data visualization module to perform a comparison to norm analysis for a given subject against a characterized population.

10. The movement monitoring system and apparatus of claim 2, wherein said wireless synchronized movement monitors, comprise:

(a) a sensor module comprising a plurality of low power solid state kinematics sensors;

(b) a microprocessor module comprising a low power microcontroller configured for device control, device status, and device communication;

(c) a data storage module comprising a solid state local storage medium;

(d) a wireless communication module comprising a low power transceiver;

(e) a data controller for robust wireless data transfer; and

(f) a power and docking module comprising a battery, an energy charging regulator circuit, and a docking connector.

11. The movement monitoring system and apparatus of claim 10, wherein said data controller of said movement monitors includes a protocol for automatically storing a plurality of data locally when an unreliable wireless channel is detected and re-transmitting said data once said wireless channel is detected as reliable.

12. The movement monitoring system and apparatus of claim 11, wherein said wireless synchronized movement monitors further comprise a wireless communication scheme, and said wireless communication scheme is a master synchronization scheme or a mesh synchronization scheme based on a statistical model of a network time and of its own clock relative to said network time.

13. The movement monitoring system and apparatus of claim 12, wherein said statistical model of said network time is a distributed statistical clock model.

14. The movement monitoring system and apparatus of claim 13, wherein said mesh synchronization scheme is based on a synchronization protocol substantially equivalent to a flooding time synchronization protocol (FTSP).

15. The movement monitoring system and apparatus of claim 14, wherein said flooding time synchronization protocol is modified such that each synchronized node broadcasts its estimated clock model parameters.

16. The movement monitoring system and apparatus of claim 10, wherein said plurality of solid state kinematics sensors include a plurality of MEMS, surface mount, low power, low noise inertial sensors including a plurality of accelerometers and gyroscopes.

17. The movement monitoring system and apparatus of claim 16, wherein said plurality of solid state kinematics sensors further include a plurality of surface mount, low power, low noise, GMR magnetometers.

18. The movement monitoring system and apparatus of claim 17, wherein said solid state local storage medium is substantially equivalent to a high capacity SD card capable of multi-day local storage of movement monitoring data at high frequencies.

19. The movement monitoring system and apparatus of claim 18, wherein said communication module includes a mode for communication with a plurality of wearable movement monitors (peer-to-peer communication) in order to synchronize said monitors, and a second mode for communication with a host computer (peer-to-host communication) to transmit sensor data.

20. The movement monitoring system and apparatus of claim 19, wherein said transceiver includes an integrated antenna, and said antenna in said wireless communication module is a bidirectional groundplane PCB patch antenna.