Porous Synthetic Vascular Grafts with Oriented Ingrowth Channels
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Abstract
A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
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Citations
72 Claims
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1-44. -44. (canceled)
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45. A method of making a prosthesis comprising the steps of:
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preparing a paste comprising a graft material solution and an extractable filler; depositing a layer of the paste onto a mandrel, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis; winding an extractable fiber onto the layer of paste; successively depositing additional layers of the paste and winding the extractable fiber onto each layer of the paste until a desired thickness of the vascular graft prosthesis is achieved; precipitating graft material from the graft material solution; and extracting the fiber from the graft material. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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59. A method of making a prosthesis comprising the steps of:
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preparing a paste comprising a graft material solution and an extractable filler; depositing a layer of the paste onto a mandrel, and simultaneously winding an extractable fiber onto the mandrel, until a desired thickness of the vascular graft prosthesis is achieved, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis; precipitating graft material from the graft material solution; and extracting the fiber from the graft material. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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Specification