FLUORESCENT AGENT CONCENTRATION MEASURING APPARATUS, DOSE CONTROL APPARATUS, ADMINISTRATION SYSTEM, FLUORESCENT AGENT CONCENTRATION MEASURING METHOD, AND DOSE CONTROL METHOD

• US 20110213562A1
• Filed: 05/11/2011
• Published: 09/01/2011
• Est. Priority Date: 01/11/2005
• Status: Active Grant

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Okawa, Atsushi
• Granted Patent: US 8,395,775 B2
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence

Abstract

A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.

Claims

1. A fluorescent agent concentration measuring apparatus comprising:

an excitation light source to radiate excitation light to a sample containing a body fluid taken from a living body administered with a fluorescent drug, the excitation light allowing the drug to emit fluorescence;

a fluorescence detection portion to detect the fluorescence;

a fluorescent agent concentration calculation portion to calculate the concentration of the drug in the living body, based on a detection signal from the fluorescence detection portion; and

a peak time estimation portion to estimate the peak time after administration of the drug into the living body, when the concentration of the drug in the living body tissue is the highest, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug, wherein,

in an optical path from the excitation light source to the fluorescence detection portion, one or more optical members and one or more optical filters are disposed, wherein each of the one or more optical members and each of the one or more optical filters have a predetermined refraction index constant in a plane orthogonal to an optical axis of the optical path.

2. The fluorescent agent concentration measuring apparatus according to claim 1, wherein the peak time estimation portion estimates the peak time based on a plurality of different times of day and the concentrations of the drug calculated at the plurality of times of day.

3. The fluorescent agent concentration measuring apparatus according to claim 2, further comprising a curve data storage portion storing a concentration-time curve data to be compared with the concentration of the drug calculated at the plurality of times of day.

4. The fluorescent agent concentration measuring apparatus according to claim 3, further comprising a communication portion to conduct transmission and reception of the data for an external server connected on the Net, wherein at least the curve data storage portion is disposed in the external server.

5. The fluorescent agent concentration measuring apparatus according to claim 1, further comprising a container loading portion to removably dispose a container including the sample solution on an optical path of the excitation light.

6. The fluorescent agent concentration measuring apparatus according to claim 5, further comprising a light shield portion to shield the container loaded in the container loading portion from the external light.

7. The fluorescent agent concentration measuring apparatus according to claim 1, wherein each of the one or more optical members has a different predetermined refraction index.

8. The fluorescent agent concentration measuring apparatus according to claim 1, wherein each of the one or more optical filters has a different predetermined refraction index.

9. A measuring apparatus comprising:

a housing; and

an opening/closing portion and an operating portion provided to the housing,

the housing including inside thereof;

a light source to generate radiation light;

a stage on which an inspection object is mounted, the stage being arranged in a radiating direction of the radiation light;

a photoreceptor arranged at a position to receive light from the inspection object;

an optical filter to transmit light having a predetermined wavelength, the optical filter being arranged in an optical path from the light source to the photoreceptor; and

a processing circuit connected to the photoreceptor, the processing circuit including;

a memory portion to store an output value from the photoreceptor at a predetermined interval;

a comparing portion to compare a measurement pattern indicating a time change of the stored output value with a prestored analytical patter; and

an estimation portion to estimate a peak time of the output value in the measurement pattern based on the comparison.

10. The measuring apparatus according to claim 9, wherein the peak time estimation portion estimates the peak time based on a plurality of different times of day and the concentrations of the drug calculated at the plurality of times of day.

11. The measuring apparatus according to claim 9, further comprising a container loading portion to removably dispose a container including the sample solution on an optical path of the excitation light.

12. The measuring apparatus according to claim 9, further comprising:

an excitation light source to radiate excitation light to a sample containing a body fluid taken from a living body administered with a fluorescent drug, the excitation light allowing the drug to emit fluorescence;

a fluorescence detection portion to detect the fluorescence;

a fluorescent agent concentration calculation portion to calculate the concentration of the drug in the living body, based on a detection signal from the fluorescence detection portion;

a peak time estimation portion to estimate the peak time after administration of the drug into the living body, when the concentration of the drug in the living body tissue is the highest, based on the elapsed time after administration of the drug to the living body and the calculated concentration of the drug, wherein,

in an optical path from the excitation light source to the fluorescence detection portion, one or more optical members and one or more optical filters are disposed, wherein each of the one or more optical members and each of the one or more optical filters have a predetermined refraction index constant in a plane orthogonal to an optical axis of the optical path;

an administration start judgment portion to judge whether a predetermined time has elapsed or not and to judge the start of administration of the drug when the predetermined time has elapsed;

a dose setting portion to set at least one of the dose and the administration time of the drug, based on the predetermined dose information of the drug after the judgment of the start of administration by the administration start judgment portion;

an output apparatus to perform at least one of functions of allowing a monitor portion to display the dose and allowing an automatic administration apparatus to administer the drug, based on the dose of the drug set by the dose setting portion; and

a living body information detection portion to detect living body function information of the living body and to transmit the living body function information to the dose setting portion.

13. The measuring apparatus according to claim 9, wherein,

in the optical path from the light source to the photoreceptor, only an optical member is disposed whose refraction factor is constant in a plane orthogonal to an optical axis of the optical path, and

the optical member includes the optical filter.

14. The measuring apparatus according to claim 9, wherein the photoreceptor and the light source are arranged to oppose to each other sandwiching the stage.