DISSOLUTION TESTING WITH INFRARED TEMPERATURE MEASUREMENT

• US 20110216805A1
• Filed: 03/02/2010
• Published: 09/08/2011
• Est. Priority Date: 03/02/2010
• Status: Abandoned Application

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Agilent Technologies, Inc.
• Inventors: Fernando, C.J. Anthony, Smit, Deon
• Application Number:
  US12/716,157
• Publication Number:
  US 20110216805A1
• Time in Patent Office: Days
• US Class Current: 374/121
• CPC Class Codes: G01N 25/482 concerning the temperature responsive elements measuring temperature or quantity of heat, thermally-sensitive elements G01K; thermoelectric devices H10N10/00, H10N15/00
• CPC Class Codes: G01N 33/15 Medicinal preparations ; Physical properties thereof, e.g. dissolubility drug screening with animal cells G01N33/5008

Abstract

A dissolution test apparatus may include a vessel support member, a sensor support member, infrared temperature sensors, and an electronic controller. The vessel support member may have apertures for receiving vessels. The infrared temperature sensors are mounted at the sensor support member. Each infrared temperature sensor is positioned proximate to a respective vessel mounting site to receive infrared radiation emitted by media contained in a vessel mounted at the vessel mounting site, and is configured to transmit a measurement signal indicative of the temperature of the media. The electronic controller communicates with the infrared temperature sensors and is configured to receive and process the measurement signals transmitted from the infrared temperature sensors. The electronic controller may be configured to control media temperature in the vessels.

Claims

1. A dissolution test apparatus, comprising:

a vessel support member comprising a plurality of vessel mounting sites for supporting a plurality of vessels, each vessel mounting site having an aperture for receiving a vessel;

a sensor support member disposed proximate to the vessel mounting sites;

a plurality of infrared temperature sensors mounted at the sensor support member, each infrared temperature sensor positioned proximate to a respective vessel mounting site to receive infrared radiation emitted by media contained in a vessel mounted at the aperture, and configured to transmit a measurement signal indicative of the temperature of the media; and

an electronic controller communicating with the plurality of infrared temperature sensors and configured to receive and process the measurement signals transmitted from the infrared temperature sensors.

2. The dissolution test apparatus of claim 1, wherein each infrared temperature sensor is positioned below a respective vessel mounting site and proximate to a side of a respective vessel mounted at the vessel mounting site to receive infrared radiation emitted by the media at the side of the vessel.

3. The dissolution test apparatus of claim 2, further comprising a plurality of vessels mounted at the respective apertures, each vessel comprising an infrared-transmitting window aligned with a respective infrared temperature sensor.

4. The dissolution test apparatus of claim 1, wherein the sensor support member comprises a plurality of vessel covers at which respective infrared temperature sensors are mounted, each vessel cover disposed at a respective aperture to cover an upper opening of a vessel mounted at the aperture.

5. The dissolution test apparatus of claim 1, wherein the sensor support member comprises a plurality of sensor support components at which respective infrared temperature sensors are mounted, each sensor support component extending over a respective aperture.

6. The dissolution test apparatus of claim 5, wherein each sensor support component is disposed on the vessel support member or on a flanged portion of a vessel mounted at the respective aperture.

7. The dissolution test apparatus of claim 5, wherein each sensor support component is a ring configured to engage the vessel support member and a vessel mounted at the respective aperture.

8. The dissolution test apparatus of claim 5, wherein each sensor support component comprises a movable portion at which respective infrared temperature sensors are mounted, and the movable portion is movable toward and away from the respective aperture to adjust a position of the infrared temperature sensor relative to the aperture.

9. The dissolution test apparatus of claim 1, further comprising a movable component positioned above the vessel support member and movable toward and away from the apertures, wherein the sensor support member is located at the movable component and is movable therewith.

10. The dissolution test apparatus of claim 1, wherein the electronic controller comprises circuitry for controlling the temperature of media contained in vessels mounted at the apertures based on the measurement signals received from the infrared temperature sensors.

11. The dissolution test apparatus of claim 10, further comprising a bath container into which vessels mounted at the respective apertures extend and a heating device communicating with the bath container, wherein the media temperature controlling circuitry communicates with the heating device.

12. The dissolution test apparatus of claim 10, further comprising a plurality of heating elements disposed in contact with respective vessels mounted at the apertures, wherein the media temperature controlling circuitry communicates with the heating elements.

13. The dissolution test apparatus of claim 12, wherein each infrared temperature sensor is positioned proximate to a respective side of a vessel to receive infrared radiation emitted by the media at the side, and each heating element comprises an opening aligned with a respective infrared temperature sensor.

14. A method for measuring temperature of dissolution media contained in respective vessels of a dissolution test apparatus, the method comprising:

inserting a plurality of vessels through respective apertures of a vessel support member of the dissolution test apparatus;

positioning a sensor support member proximate to the vessels such that a plurality of infrared temperature sensors supported by the sensor support member are positioned proximate to respective interiors of the vessels without being submerged in volumes of dissolution media respectively contained in the vessels;

heating the respective volumes of dissolution media; and

non-invasively monitoring the temperatures of the respective volumes of dissolution media by operating the infrared temperature sensors to receive infrared radiation emitted from the respective volumes of dissolution media, generating measurement signals indicative of the temperatures of the respective volumes of dissolution media, and transmitting the measurement signals to an electronic controller of the dissolution test apparatus.

15. The method of claim 14, wherein positioning the sensor support member comprises positioning each infrared temperature sensor below a respective aperture to receive infrared radiation emitted by the media at a side of the vessel mounted at the aperture.

16. The method of claim 14, wherein the sensor support member comprises a plurality of vessel covers at which respective infrared temperature sensors are mounted, and positioning the sensor support member comprises covering the upper openings of the vessels with respective vessel covers.

17. The method of claim 14, wherein the sensor support member comprises a plurality of sensor support components at which respective infrared temperature sensors are mounted, and positioning the sensor support member comprises positioning the sensor support components proximate to respective upper openings of the vessels.

18. The method of claim 14, wherein the sensor support member is coupled to the dissolution test apparatus, and positioning the sensor support member comprises operating the dissolution test apparatus to move the sensor support member toward the vessels.

19. The method of claim 14, wherein heating comprises operating a heating device to maintain a heated bath in contact with the vessels, and further comprising controlling the temperatures of the respective volumes of dissolution media based on the transmitted measurement signals by operating the electronic controller to control the heating device.

20. The method of claim 14, wherein heating comprises operating a plurality of heating elements in contact with the vessels, and further comprising controlling the temperatures of the respective volumes of dissolution media based on the transmitted measurement signals by operating the electronic controller to control the heating elements.