IMMUNOPOTENTIATING COMPOSITION

• US 20110217366A1
• Filed: 05/17/2011
• Published: 09/08/2011
• Est. Priority Date: 05/19/1997
• Status: Abandoned Application

• Current Assignee: Konen Company Limited, Dainippon Sumitomo Pharma Company Limited (Sumitomo Chemical Company Limited), University of Melbourne
• Original Assignee: Konen Company Limited, Dainippon Sumitomo Pharma Company Limited (Sumitomo Chemical Company Limited), University of Melbourne
• Inventors: Sano, Akihiko, Nash, Andrew Donald, Nagahara, Shunji, Lofthouse, Shari, Brandon, Malcolm Roy, FUJIOKA, Keiji
• Application Number:
  US13/109,949
• Publication Number:
  US 20110217366A1
• Time in Patent Office: Days
• US Class Current: 424/450
• CPC Class Codes: A61K 39/39 characterised by the immunostimulating additives, e.g. chemical adjuvants
• CPC Class Codes: A61K 47/42 Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein oligopeptides having up to five amino acids A61K47/183; polyamino acids A61K47/34
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0092 Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/00 Antiparasitic agents
• CPC Class Codes: A61P 37/04 Immunostimulants

Abstract

The present invention provides an immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising a biocompatible material for effectively increasing an immune response derived from an antigen. The present invention further provides a method of producing an antibody by administering said immunopotentiating composition to a mammal or bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.

Claims

1. An immunopotentiating composition which comprises an antigen or antigen-inducing substance, and a carrier comprising collagen or polydimethylsiloxane.

2. An immunopotentiating composition as claimed in claim 1 which further comprises at least one pharmaceutical additive.

3. An immunopotentiating composition as claimed in claim 1, wherein the antigen or antigen-inducing substance is capable of inducing an immune response specific to a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells.

4. An immunopotentiating composition as claimed in claim 3, wherein the antigen or antigen-inducing substance is a substance obtained by using the chemical technology, recombinant DNA technology, cell culture technology or fermentation technology.

5. An immunopotentiating composition as claimed in claim 3, wherein the antigen is derived from a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells, by attenuation, detoxification or rendering the same nonpathogenic.

6. An immunopotentiating composition as claimed in claim 3, wherein the antigen or antigen-inducing substance is a substance obtained from a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells.

7. An immunopotentiating composition as claimed in claim 3, wherein the antigen-inducing substance is a plasmid or virus with a nucleic acid (gene sequence) coding for an antigen capable of inducing an immune response specific to a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells as incorporated therein so that said antigen can be produced in vivo.

8. An immunopotentiating composition as claimed in claim 1, wherein said composition is a solution, suspension, gel, film, sponge, rod or bar, or minute particles.

18. An immunopotentiating composition as claimed in claim 1, wherein the antigen is a superantigen.

19. An immunopotentiating composition as claimed in claim 1, wherein the antigen-inducting substance is a plasmid or virus with a nucleic acid (gene sequence) coding superantigen as incorporated therein so that said superantigen can be produced in vivo.

22. An immunopotentiating composition as claimed in claim 1, wherein said composition is of a bar or rod-like shape.

23. An immunopotentiating composition as claimed in claim 22, wherein said composition is of a coated or covered rod-like shape.

24. An immunopotentiating composition as claimed in claim 23, wherein the carrier is a polydimethylsiloxane.

25. An immunopotentiating composition as claimed in claim 22, which, in use, exhibits a modified release profile.

26. An immunopotentiating composition as claimed in claim 25, which, in use, exhibits a sustained release profile.

29. A method of producing an antibody which comprises administering the immunopotentiating composition of claim 1 or 9 to a human being, to a mammal other than human being or to a bird, thereby modulating the immune response in said mammal or bird and recovering the antibody produced.

9. An immunopotentiating composition which comprises an antigen or antigen-inducing substance, a substance having immunoactivating, immunostimulating or immunomodulating activity, and a carrier comprising collagen or polydimethylsiloxane.

10. An immunopotentiating composition as claimed in claim 9, wherein the substance having immunoactivating, immunostimulating or immunomodulating activity is a cytokine.

11. An immunopotentiating composition as claimed in claim 9, which further comprises at least one pharmaceutical additive.

12. An immunopotentiating composition as claimed in claim 9, wherein the antigen or antigen-inducing substance is capable of inducing an immune response specific to a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells.

13. An immunopotentiating composition as claimed in claim 12, wherein the antigen or antigen-inducing substance is a substance obtained by using the chemical technology, recombinant DNA technology, cell culture technology or fermentation technology.

14. An immunopotentiating composition as claimed in claim 12, wherein the antigen is derived from a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells by attenuation, detoxification or rendering the same non-pathogenic.

15. An immunopotentiating composition as claimed in claim 12, wherein the antigen or antigen-inducing substance is a substance obtained from a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells.

16. An immunopotentiating composition as claimed in claim 12, wherein the antigen-inducing substance is a plasmid or virus with a nucleic acid (gene sequence) coding for an antigen capable of inducing an immune response specific to a member of the group consisting of viruses, mycoplasmata, bacteria, parasites, toxins and tumor cells as incorporated therein so that said antigen can be produced in vivo.

17. An immunopotentiating composition as claimed in claim 9, wherein said composition is a solution, suspension, gel, film, sponge, rod or bar, or minute particles.

20. An immunopotentiating composition as claimed in claim 9, wherein the antigen is a superantigen.

21. An immunopotentiating composition as claimed in claim 9, wherein the antigen-inducting substance is a plasmid or virus with a nucleic acid (gene sequence) coding superantigen as incorporated therein so that said superantigen can be produced in vivo.

27. An immunopotentiating composition as claimed in claim 9 wherein the substance having immunoactivating, immunostimulating or immunomodulating activity is an adjuvant selected from the group consisting of cytokines, chemokines, growth factors, adjuvant peptides and DNA sequences, alum, Freund'"'"'s complete adjuvant, Freund'"'"'s incomplete adjuvant, iscom, saponins, hexadecylamine, dimethyldioctadecylammonium bromide, Abridin, cell wall skeletal components, cholera toxin, lipopolysaccharide endotoxins, and liposomes.

28. An immunopotentiating composition as claimed in claim 10, wherein the cytokine is included in the composition in the absence of a solvent.

30. A method for the prophylactic or therapeutic treatment of disease or other disorder, which process includes:

providing an immunopotentiating composition comprising

collagen or polydimethylsiloxane,

an antigen or antigen-inducing substance; and

administering to a recipient an effective amount of the immunopotentiating composition.

31. A method according to claim 30 wherein the immunopotentiating composition further includes an immunomodulating agent.

32. A method according to claim 31 wherein the recipient is a human being, a mammal other than human being, or a bird.