MAGNETIC NANOMATERIALS AND METHODS FOR CHEMOEMBOLISATION

• US 20110217379A1
• Filed: 03/04/2011
• Published: 09/08/2011
• Est. Priority Date: 03/08/2010
• Status: Abandoned Application

• Current Assignee: Chinese University of Hong Kong
• Original Assignee: The Davis Companies
• Inventors: Qin, Ling, Leung, Ken Cham-Fai, Cheng, Chris Hon Ki, Wang, Yixiang
• Application Number:
  US13/040,873
• Publication Number:
  US 20110217379A1
• Time in Patent Office: Days
• US Class Current: 424/486
• CPC Class Codes: A61K 31/745 Polymers of hydrocarbons
• CPC Class Codes: A61K 31/765 Polymers containing oxygen
• CPC Class Codes: A61K 41/0028 Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/50 Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals A61K9/2081 takes precedence; particles with a single coating comprising drug A61K9/167
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices artificial blood vessels A61L27/507
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C08L 29/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids

Abstract

There are disclosed magnetic nanoparticles and embolisation compositions comprising the nanoparticles. There are also disclosed methods to make the nanoparticles and embolisation compositions and methods to deliver therapeutic agents to a subject.

Claims

1. An embolization composition comprising:

a biodegradable matrix encapsulating at least one nanoparticle, wherein degradation of the matrix releases the nanoparticle.

2. The embolisation composition according to claim 1 wherein the nanoparticle is hollow.

3. The embolisation composition according to claim 2 wherein the nanoparticle is a superparamagnetic porous nanoparticle.

4. The embolisation composition according to claim 2 wherein said nanoparticle contains a therapeutically effective amount of a therapeutic agent.

5. The embolisation composition according to claim 1 wherein the matrix comprises PVA.

6. The embolisation composition according to claim 4 wherein the therapeutic agent is an anticancer agent.

7. The embolisation composition according to claim 1 wherein the nanoparticle is coated with:

a separating agent;

or

a targeting agent;

or

a separating agent and a targeting agent.

8. A method of selectively obstructing blood flow in a blood vessel in a patient, the method comprising the steps of:

administering to the patient an embolization composition according to claim 1 for purposively inducing an embolism in said patient blood vessel.

9. A method for delivering a therapeutic agent to a patient, the method comprising the steps of:

administering to the patient an embolisation composition according to claim 1 that contains the therapeutic agent; and

releasing the therapeutic agent.

10. The method according to claim 9 wherein the method further comprises introducing said embolisation composition into a blood vessel supplying blood to a target region.

11. The method according to claim 9 further comprising the step of applying a magnetic field to position said embolisation composition.

12. The method according to claim 10 wherein said target region comprises a tumor.

15. The method according to claim 9 wherein said nanoparticle is a hollow, superparamagnetic nanoparticle.

13. A method for making an embolisation composition, the method comprising the step of embedding at least one nanoparticle in a degradable matrix to thereby form the embolisation composition.

14. The method according to claim 13 wherein said nanoparticle contains a therapeutic agent.

16. The method according to claim 14 wherein when said matrix suppresses the release of said therapeutic agent.

17. The method according to claim 14 wherein the therapeutic agent is an anticancer agent.

18. The method according to claim 13 wherein the nanoparticle is coated with:

a separating agent;

or

a targeting agent;

or

a separating agent and a targeting agent.

19. A method for inhibiting growth of a cancer, the method comprising the step of inhibiting the blood supply to said cancer with a degradable embolisation composition

said embolisation composition comprising a degradable matrix, a plurality of magnetic nanoparticles, and a therapeutically effective amount of an anticancer agent.

20. The method according to claim 19 wherein said nanoparticles are embedded in said matrix and carry said therapeutic agent, and wherein said method further comprises the steps of:

allowing ones of said nanoparticles to escape from the blood vessel carrying said blood supply; and

releasing the anticancer agent from said nanoparticles.