ANTI-IL-6 ANTIBODIES, COMPOSITIONS, METHODS AND USES
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
68 Citations
41 Claims
-
1. (canceled)
-
2. (canceled)
- 3. An isolated antibody or antibody fragment that binds to human IL-6 comprising a heavy chain variable domain and a light chain variable domain containing complementarity determining regions (CDRs), and a constant region derived from one or more human antibodies, wherein the heavy chain variable domain comprises the CDR3 of SEQ ID No. 3.
-
5-21. -21. (canceled)
-
23-39. -39. (canceled)
- 40. An isolated IL-6 antibody or fragment thereof, comprising a murine variable and human constant region, wherein said antibody or specified portion or variant specifically binds at least one epitope comprising amino acids Gln29-Lev34 of human IL-6.
Specification