PERFUSION DETECTION DEVICES AND METHODS OF USING THE SAME

• US 20110218448A1
• Filed: 03/03/2010
• Published: 09/08/2011
• Est. Priority Date: 03/03/2010
• Status: Abandoned Application

• Current Assignee: Rudolf F. Buntic
• Original Assignee: Rudolf F. Buntic
• Inventors: Buntic, Rudolf F.
• Application Number:
  US12/717,056
• Publication Number:
  US 20110218448A1
• Time in Patent Office: Days
• US Class Current: 600/504
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light

Abstract

Hand-held pocket-sized self-contained perfusion detection devices are provided. Devices of the invention are configured to rapidly provide a perfusion detection result without the need for pre-calibration. Also provided are methods of using the perfusion detection devices, as well as kits that include the devices and/or components thereof for use in practicing such methods.

Claims

1. A hand-held perfusion detection device, said device comprising:

a power source;

a light source;

a detector; and

a processor configured to provide a perfusion detection result in 1 minute or less following illumination of a target tissue site with light from the light emitting diode without pre-calibration;

wherein the power source, light emitting diode, detector and processor are present in a self-contained pocket-sized housing.

2. The device according to claim 1, wherein the processor is configured to provide a perfusion detection result substantially immediately.

3. The device according to claim 2, wherein the light source is a light emitting diode.

4. The device according to claim 1, wherein the detector is a photodiode.

5. The device according to claim 4, wherein the device comprises a signal amplifier coupled to the photodiode.

6. The device according to claim 5, wherein the signal amplifier and photodiode are present in an EMI shield.

7. The device according to claim 1, wherein the device comprises a wave generator configured to provide a pulse-wave signal to the light emitting diode.

8. The device according to claim 7, wherein the device comprises a lock-in amplifier configured to receive a signal from the detector.

9. The device according to claim 8, wherein the lock-in amplifier is configured to receive a pulse-wave reference signal from the wave generator.

10. The device according to claim 8, wherein the device comprises a root mean square converter configured to receive a signal from the lock-in amplifier.

11. The device according to claim 10, wherein the device comprises low pass filter configured to receive a signal from the root mean square converter.

12. The device according to claim 11, wherein the processor comprises an analog to digital signal converter configured to receive a signal from the low pass filter and output a digital signal to a functional block that converts the digital signal to the perfusion detection result.

13. The device according to claim 12, wherein the processor further comprises the wave generator.

14. The device according to claim 13, wherein the device comprises a display configured to display the perfusion detection result.

15. The device according to claim 1, wherein the device comprises an interchangeable filter operably positioned relative to the detector.

16. The device according to claim 1, wherein the light emitting diode is interchangeable.

17. The device according to claim 1, wherein the processor comprises a wave generator having a frequency that is programmably adjustable.

18. The device according to claim 17, wherein the frequency can be programmably adjusted to frequency ranging from 1 Hz to 1 MHz.

19. The device according to claim 1, wherein the power source is a battery.

20. The device according to claim 1, wherein the housing comprises a body section and head section.

21. The device according to claim 20, wherein the head section is movable relative to the body section.

22. The device according to claim 21, wherein the head section comprises the detector and the body section comprises the power source, light emitting diode and processor.

23. The device according to claim 22, wherein the device is configured to emit and receive light through a common aperture.

24. The device according to claim 23, wherein the device comprises an ambient light shield configured to shield the detector from ambient light.

25. The device according to claim 24, wherein the ambient light shield is a speculum.

29. The method according to claim 16, wherein the perfusion detection result is obtained in 1 minute or less following illumination of the target tissue with the light emitting diode.

30. The method according to claim 29, wherein the perfusion detection result is obtained in 5 seconds or less following illumination of the target tissue with the light emitting diode.

26. A method comprising:

administering a fluorescent agent to the subject; and

obtaining a perfusion detection result for target tissue from a hand-held perfusion detection device comprising;

a power source;

a light emitting diode;

a detector; and

a processor configured to provide a perfusion detection result in 1 minute or less following illumination of a target tissue site with light from the light emitting diode without pre-calibration;

wherein the power source, light emitting diode, detector and processor are present in a self-contained pocket-sized housing.

27. The method according to claim 26, wherein the fluorescent agent is administered to the subject by injection.

28. The method according to claim 26, wherein the fluorescent agent is fluorescein.

31. A kit comprising:

(a) a hand-held perfusion detection device, said device comprising;

a power source;

a light emitting diode;

a detector; and

a processor configured to provide a perfusion detection result in 1 minute or less following illumination of a target tissue site with light from the light emitting diode without pre-calibration;

wherein the power source, light emitting diode, detector and processor are present in a self-contained pocket-sized housing; and

(b) instructions for using the device in a perfusion detection application.

32. The kit according to claim 31, wherein the kit further comprises a dosage of a fluorescent agent.

33. The kit according to claim 31, wherein the kit further comprises two or more light emitting diodes of differing light emission properties.

34. The kit according to claim 33, wherein the kit further comprises two or more differing optical filters configured to be operably positioned in the device relative to the detector.