Methods and Devices for Programmable Delivery of Microdoses of Liquid Drugs
First Claim
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1. A fluid delivery device, comprising:
- (a) a replaceable cartridge located in a first housing, wherein the replaceable cartridge comprises;
a reservoir comprising at least one expandable element made of resilient material, said reservoir having at least two spatially separated sections connected so that hydraulic resistance between said two sections is not less than non-zero R1; and
a flow passage connecting an internal volume of said reservoir with at least one exit opening so that under conditions of fluid flow, hydraulic resistance to flow of said flow passage is not less than predetermined non-zero R2;
(b) an actuating module located in a second housing, said module comprising;
a driving force system; and
at least part of a sensor system, wherein said part of the sensor system is capable of producing an output associated with at least one geometric parameter of said expandable element;
(c) a connector to provide a temporary connection of said replaceable cartridge and said actuating module; and
(d) a programmable processor with fluid delivery instructions stored therein, said processor capable of acquiring said output of the sensor system and capable of producing an other output, said other output controlling the driving force system;
whereaswhen both housings are connected to each other, the driving force system is capable of applying a force changing over time to the fluid in the reservoir.
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Abstract
Devices of this invention include replaceable cartridges for delivery of doses of fluids. Cartridges having a fluid supply reservoir comprising an expandable element are designed to be connected with non-disposable actuating module supplied with a sensor, a mechanism to apply a force to the fluid, thereby forcing a predetermined dose out of the reservoir, and a processor providing control outputs from a sensor system according to preprogrammed instructions. Methods of this invention include delivery of microdoses of fluids using devices of this invention.
42 Citations
44 Claims
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1. A fluid delivery device, comprising:
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(a) a replaceable cartridge located in a first housing, wherein the replaceable cartridge comprises; a reservoir comprising at least one expandable element made of resilient material, said reservoir having at least two spatially separated sections connected so that hydraulic resistance between said two sections is not less than non-zero R1; and a flow passage connecting an internal volume of said reservoir with at least one exit opening so that under conditions of fluid flow, hydraulic resistance to flow of said flow passage is not less than predetermined non-zero R2; (b) an actuating module located in a second housing, said module comprising; a driving force system; and at least part of a sensor system, wherein said part of the sensor system is capable of producing an output associated with at least one geometric parameter of said expandable element; (c) a connector to provide a temporary connection of said replaceable cartridge and said actuating module; and (d) a programmable processor with fluid delivery instructions stored therein, said processor capable of acquiring said output of the sensor system and capable of producing an other output, said other output controlling the driving force system;
whereaswhen both housings are connected to each other, the driving force system is capable of applying a force changing over time to the fluid in the reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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22. A replaceable cartridge for a fluid delivery device, comprising:
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(a) a reservoir adapted to be filled with a fluid, said reservoir having at least two spatially separated sections, a first section of said two sections comprising at least one expandable element made of resilient material, said two sections connected to each other so that under conditions of fluid flow, hydraulic resistance between them is not less than non-zero R1; (b) a flow passage connecting at least one exit opening with an internal volume of said first section which comprises said at least one expandable element made of resilient material so that under conditions of fluid flow, hydraulic resistance of said flow passage is not less than predetermined non-zero R2; and (c) at least a portion of a connector to at least temporarily operably connect said cartridge with a housing containing an actuator; wherein said connector provides that relative locations of said reservoir and said housing containing said actuator to permit transfer a force from said actuator to internal surface of a second section of said two sections of said reservoir. - View Dependent Claims (23)
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24. An actuator module for a fluid delivery device, comprising:
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(a) a housing having; a driving force system; and at least part of a sensor system, wherein said part of the sensor system is capable of producing an output associated with at least one geometric parameter of an expandable element of a replaceable cartridge having a reservoir; (b) at least a portion of a connector to provide a temporary operable connection to a replaceable cartridge having a reservoir adapted to hold said fluid; and (c) a programmable processor with fluid delivery instructions stored therein, said processor capable of acquiring said output of the sensor system and capable of producing an other output, said other output controlling said driving force system;
whereinwhen said actuator and said replaceable cartridge are connected to each other, said driving force system is capable of applying a force changing over time to a fluid in the reservoir. - View Dependent Claims (25, 26, 27)
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42. A method for a delivery of a predetermined dose of a fluid, comprising the steps:
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(a) providing a device comprising a replaceable cartridge comprising a reservoir filled with the fluid, said reservoir having both at least one element made of resilient material and at least one exit opening, and a separable actuator module connected with said cartridge, said actuator module capable of switching between at least two stable states, wherein only one of two said states results in a continuous compressive force applied to the fluid; (b) switching said module into a stable state which results in producing of a continuous compressive force applied to the fluid in said reservoir; (c) acquiring at least one output from a sensor system associated with at least one geometric parameter of said resilient element; (d) calculating a time tend, comprising treating said acquired output by a processor capable of executing commands stored in said processor; and (e) switching said module into said other stable state at tend.
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43. A processor for a drug-delivery system, comprising:
said processor capable of processing computer implemented instructions for calculating an amount of fluid to be delivered, said instructions comprising a formula selected from the group consisting of equations 9 (Eq.
9), Eq. 11, Eq. 12, Eq. 13, Eq. 14, and Eq. 30.
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44. A computer readable medium, comprising:
a physical medium having computer implementable instructions thereon for calculating an amount of fluid to be delivered, said instructions comprising a formula selected from the group consisting of equations 9 (Eq.
9), Eq. 11, Eq. 12, Eq. 13, Eq. 14, and Eq. 30, wherein said medium is in physical form.
Specification