NITRIC OXIDE DELIVERY SYSTEM

• US 20110220103A1
• Filed: 11/22/2010
• Published: 09/15/2011
• Est. Priority Date: 11/20/2009
• Status: Active Grant

• Current Assignee: GENO LLC
• Original Assignee: GENO LLC
• Inventors: Denton, Ryan, Fuller, Jody, Johnson, Bryan, Fine, David H., Vasquez, Gregory
• Granted Patent: US 8,646,445 B2
• Time in Patent Office: Days
• US Class Current: 128/202.26
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61M 16/0057 Pumps therefor
• CPC Class Codes: A61M 16/0066 Blowers or centrifugal pumps
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2202/0275 Nitric oxide [NO]
• CPC Class Codes: A61M 2205/8206 battery-operated

Abstract

An ambulatory or stationary device for delivery of a therapeutic amount of nitric oxide to an individual'"'"'s lungs.

Claims

1. A system for delivering a therapeutic amount of nitric oxide, comprising:

a liquid reservoir containing dinitrogen tetroxide;

a tube coupled to the reservoir;

a first ribbed tube coupled to the tube;

wherein the tube comprises a surface-activated material with a reducing agent and

a patient interface coupled to the first ribbed tube, wherein the tube converts nitrogen dioxide into nitric oxide prior to reaching the patient interface.

2. The system of claim 1, wherein the tube is a quartz tube.

3. The system of claim 1, wherein the tube is silica tube.

4. The system of claim 1, wherein the tube has a bore size of about 50 microns.

5. The system of claim 1, wherein the tube has a bore size of about 25 microns or less.

6. The system of claim 1, wherein the tube has a bore size of 10 microns or less.

7. The system of claim 1, further comprising a valve coupled to the reservoir and the tube.

8. The system of claim 1, wherein the tube is sealed before use.

9. The system of claim 1, further comprising an air pump in communication with the reservoir.

10. The system of claim 9 wherein the pump is a battery-driven pump.

11. The system of claim 1, further comprising a heating element associated with the reservoir.

12. The system of claim 1, wherein the patient interface is a mouth piece, nasal cannula, face mask, fully-sealed face mask or an endotracheal tube connected to a ventilator or anesthesia machine.

13. The system of claim 1, wherein the reservoir contains compressed nitrogen dioxide with or without a diluent gas.

14. The system of claim 1, wherein the reservoir further includes nitrogen, air, oxygen-enriched air, or substantially pure oxygen.

15. The system of claim 1, wherein the surface-activated material is a silica gel.

16. The system of claim 1, further comprising a second ribbed tube comprising a surface-activated material and a reducing agent.

17. The system of claim 1, wherein the patient interface is a delivery tube to the patient'"'"'s mouth or nose or an endotracheal tube attached to a ventilator or an anesthesia machine.

18. The system of claim 1, wherein the system is adapted to be worn on a patient'"'"'s body.

19. The system of claim 1, wherein the reservoir is spherical.

20. The system of claim 1, wherein the reservoir is a fused silica reservoir.

21. The system of claim 1, wherein the reservoir is a non-reactive metal reservoir.

22. The system of claim 21, wherein the non-reactive metal is palladium, silver, platinum, gold, aluminum or stainless steel.

23. The system of claim 21, wherein the reservoir is an aluminum reservoir.

24. The system of claim 21, wherein the reservoir is a stainless steel reservoir.

25. The system of claim 1, further comprising an insulation covering the reservoir and the tube.

26. The system of claim 25, wherein the insulation covering further comprises an alkaline solution.

27. The system of claim 26, wherein the alkaline solution is calcium oxide, sodium hydroxide, sodium carbonate, potassium hydroxide, ammonium hydroxide, sodium silicate.

28. The system of claim 1, further comprising a source of pressurized inhalable gas.

29. The system of claim 28, wherein the gas is air or oxygen.

30. The system of claim 1, wherein the reducing agent is an antioxidant.

31. The system of claim 30, wherein the antioxidant is an aqueous solution of an antioxidant.

32. The system of claim 30, wherein the antioxidant is ascorbic acid, alpha tocopherol, or gamma tocopherol.

33. A device for delivering nitric oxide to a patient comprising:

a liquid reservoir containing dinitrogen tetroxide;

a tube coupled to the reservoir, wherein tube has a bore size of about 25 microns or less;

a first ribbed tube comprising a surface-activated material saturated with an aqueous solution of an antioxidant, that is coupled to the tube; and

a patient interface coupled to the first ribbed tube, wherein the first ribbed tube converts nitrogen dioxide into nitric oxide prior to reaching the patient interface.

34. The device of claim 33, further comprising a heating element associated with the reservoir.

35. The device of claim 33, comprising an air pump in communication with the reservoir.

36. The device of claim 33, wherein the pump is a battery-driven pump.

37. The device of claim 33, further comprising a nitrogen dioxide and/or a nitric oxide monitor.

38. The device of claim 37 where the nitrogen dioxide and/or nitric oxide monitor is mounted in the wall of the tubing that is delivering the gas to the patient.

39. The device of claim 38 where the nitrogen dioxide and nitric oxide monitors are calibrated automatically at certain time intervals.

40. A hollow tube comprising a body having a first end and a second end, wherein the body comprises multiple concentric hollow ribs and contains a surface-activated material.

41. The tube of claim 40, wherein the surface-activated material is saturated with an aqueous solution of an antioxidant to convert nitrogen dioxide into nitric oxide.

42. The tube of claim 40, wherein the surface-activated material comprises a silica gel, activated charcoal, activated carbon, activated alumina or calcium sulfate.