HIGH DENSITY PLATE FILLER
First Claim
1. A filling apparatus for filling a microplate, the microplate having a plurality of wells, each of the plurality of wells being sized to receive an assay therein, the filling apparatus comprising:
- a substrate having a first surface and an opposing second surface, the substrate further having an assay input port, and a plurality of microfluidic channels;
a plurality of staging capillaries extending through the substrate, each of the plurality of staging capillaries having an inlet and an outlet, wherein at least one of the plurality of microfluidic channels is in fluid communication with the assay input port and at least two of the plurality of staging capillaries; and
wherein each of the plurality of staging capillaries is spaced relative to adjacent ones of the plurality of staging capillaries to permit filling of the microplate.
3 Assignments
0 Petitions
Accused Products
Abstract
A filling apparatus for filling a microplate. The microplate can comprise a plurality of wells each sized to receive an assay. A substrate can comprise a first surface and an opposing second surface, a first assay input port for receiving the assay disposed on the first surface, a plurality of staging capillaries extending through the substrate, and a first plurality of microfluidic channels fluidly coupling the first assay input port with at least one of the plurality of staging capillaries. Each of the plurality of staging capillaries can comprise an inlet and an outlet and be sized to receive the assay.
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Citations
13 Claims
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1. A filling apparatus for filling a microplate, the microplate having a plurality of wells, each of the plurality of wells being sized to receive an assay therein, the filling apparatus comprising:
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a substrate having a first surface and an opposing second surface, the substrate further having an assay input port, and a plurality of microfluidic channels; a plurality of staging capillaries extending through the substrate, each of the plurality of staging capillaries having an inlet and an outlet, wherein at least one of the plurality of microfluidic channels is in fluid communication with the assay input port and at least two of the plurality of staging capillaries; and wherein each of the plurality of staging capillaries is spaced relative to adjacent ones of the plurality of staging capillaries to permit filling of the microplate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A filling apparatus for filling a microplate, comprising:
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a microplate comprising a plurality of openings for receiving one or more solutions, the openings defining a plurality of groups each including more than one of the openings; a first substrate comprising a plurality of input ports corresponding to the plurality of groups and configured to receive the one or more solutions; and a second substrate disposed between the first substrate and the microplate, the second substrate comprising a plurality of channels providing fluid communication between corresponding ones of the input ports and the groups of openings. - View Dependent Claims (11)
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12. A method of filling a microplate, comprising:
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providing a filling apparatus including; a microplate comprising a plurality of openings for receiving one or more solutions, the openings defining a plurality of groups including more than one of the openings; a first substrate comprising a plurality of input ports corresponding to the plurality of groups and configured to receive the one or more solutions; and a second substrate disposed between the first substrate and the microplate, the second substrate comprising a plurality of channels providing fluid communication between corresponding ones of the input ports and the groups of openings; introducing a respective solution into corresponding ones of the input port; flowing the respective solutions from the first substrate to the openings of the microplate via the second substrate. - View Dependent Claims (13)
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Specification