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LYSOSOMAL TARGETING PEPTIDES AND USES THEREOF

  • US 20110223147A1
  • Filed: 05/07/2009
  • Published: 09/15/2011
  • Est. Priority Date: 05/07/2008
  • Status: Abandoned Application
First Claim
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1. A targeted therapeutic fusion protein comprising:

  • a lysosomal enzyme; and

    an IGF-II mutein having an amino acid sequence at least 70% identical to mature human IGF-II (SEQ ID NO;

    1), wherein the IGF-II mutein is resistant to furin cleavage and binds to the human cation-independent mannose-6-phosphate receptor in a mannose-6-phosphate-independent manner.

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