MEASUREMENT DEVICES AND METHODS FOR MEASURING ANALYTE CONCENTRATION INCORPORATING TEMPERATURE AND PH CORRECTION
First Claim
1. A method of estimating an analyte concentration in a physiologic fluid, comprising:
- contacting an analyte sensing element with the fluid, wherein the analyte sensing element is configured to generate a signal indicative of the analyte concentration in the fluid;
detecting the signal indicative of the analyte concentration;
contacting a temperature sensing element with the fluid, wherein the temperature sensing element is configured to generate a signal indicative of a temperature of the fluid;
detecting the signal indicative of the temperature of the fluid; and
transforming the detected signal indicative of the analyte concentration utilizing a modified Michaelis-Menten equation comprising Michaelis-Menten parameters, wherein the Michaelis-Menten parameters are set based on data comprising;
temperature calibration data; and
the detected signal indicative of temperature.
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Abstract
Disclosed herein are methods of estimating an analyte concentration which include generating a signal indicative of the analyte concentration, generating a signal indicative of a temperature, generating a signal indicative of a pH, and transforming the signal indicative of the analyte concentration utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data which includes temperature and pH calibration parameters, the signal indicative of a temperature, and the signal indicative of a pH. Also disclosed herein are measurement devices which employ the aforementioned methods.
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Citations
35 Claims
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1. A method of estimating an analyte concentration in a physiologic fluid, comprising:
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contacting an analyte sensing element with the fluid, wherein the analyte sensing element is configured to generate a signal indicative of the analyte concentration in the fluid; detecting the signal indicative of the analyte concentration; contacting a temperature sensing element with the fluid, wherein the temperature sensing element is configured to generate a signal indicative of a temperature of the fluid; detecting the signal indicative of the temperature of the fluid; and transforming the detected signal indicative of the analyte concentration utilizing a modified Michaelis-Menten equation comprising Michaelis-Menten parameters, wherein the Michaelis-Menten parameters are set based on data comprising; temperature calibration data; and the detected signal indicative of temperature. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of estimating an analyte concentration in a physiologic fluid, comprising:
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contacting an analyte sensing element with the fluid, wherein the analyte sensing element is configured to generate a signal indicative of the analyte concentration in the fluid; detecting the signal indicative of the analyte concentration; contacting a pH sensing element with the fluid, wherein the pH sensing element is configured to generate a signal indicative of a pH of the fluid; detecting the signal indicative of the pH of the fluid; and transforming the signal indicative of the analyte concentration utilizing a modified Michaelis-Menten equation comprising Michaelis-Menten parameters, wherein the Michaelis-Menten parameters are set based on data comprising; pH calibration data; and the detected signal indicative of pH. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A method of estimating an analyte concentration in a physiologic fluid comprising:
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contacting an analyte sensor with the fluid, wherein the analyte sensor is configured to generate a signal indicative of the analyte concentration; detecting the signal indicative of the analyte concentration; contacting a temperature sensing element configured to generate a signal indicative of a temperature; detecting the signal indicative of the temperature; contacting a pH sensing element configured to generate a signal indicative of a pH; detecting the signal indicative of the pH; and transforming the signal indicative of the analyte concentration utilizing a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein the Michaelis-Menten parameters are set based on data comprising; temperature and pH calibration data; the detected signal indicative of temperature; and the detected signal indicative of pH. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26)
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27. A measurement device for estimating an analyte concentration comprising:
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an analyte sensing element configured to generate a first signal indicative of the analyte concentration; a temperature sensing element configured to generate a second signal indicative of a temperature; and a receiving and processing unit configured to transform the first signal utilizing a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data comprising; temperature calibration data; and the second signal. - View Dependent Claims (35)
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28. A measurement device for estimating an analyte concentration comprising:
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an analyte sensor configured to generate a first signal indicative of the analyte concentration; a pH sensor configured to generate a second signal, the second signal indicative of a pH; and a receiving and processing unit configured to transform the first signal utilizing a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein values of the Michaelis-Menten parameters are set based upon data comprising; pH calibration data; and the second signal. - View Dependent Claims (29, 30, 34)
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31. A measurement device for estimating an analyte concentration of a sample, the measurement device comprising:
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an analyte and pH sensor configured to generate; a first signal indicative of the analyte concentration of the sample and a pH of the sample; and a second signal indicative of the analyte concentration of the sample and the pH of the sample; and a receiving and processing unit configured to transform a third signal utilizing an equation of the form of a modified Michaelis-Menten equation depending on Michaelis-Menten parameters, wherein the third signal is indicative of the analyte concentration and is generated based upon data comprising the first signal and the second signal, and wherein values of the Michaelis-Menten parameters are set based upon data comprising; pH calibration data; and a fourth signal, the fourth signal indicative of the pH and generated based upon data comprising the first signal and the second signal. - View Dependent Claims (32, 33)
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Specification