METHOD AND APPARATUS FOR SELECTIVE PHOTOTHERMOLYSIS OF VEINS

• US 20110224656A1
• Filed: 04/01/2009
• Published: 09/15/2011
• Est. Priority Date: 04/03/2008
• Status: Abandoned Application

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Farinelli, William A., Rubin, Iris, Anderson, Richard Rox
• Application Number:
  US12/936,348
• Publication Number:
  US 20110224656A1
• Time in Patent Office: Days
• US Class Current: 606/3
• CPC Class Codes: A61N 2005/0602 for treatment of blood vessels
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/06 using light
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning

Abstract

Exemplary embodiments of the present disclosure provide method and apparatus for providing electromagnetic radiation to a biological tissue that may be selectively absorbed by venous structures as compared to arteries. For example, a wavelength of the electromagnetic radiation can be selected based on absorptivity of the radiation by oxygenated hemoglobin, deoxygenated hemoglobin, and/or met-hemoglobin. The wavelength can be, e.g., between about 685 nm and about 705 nm, or between about 690 nm and about 700 nm, or about 694 nm. The exemplary methods and apparatus can be used, e.g., for photothermolysis treatment of venous structures such as port wine stains or varicose veins, while reducing or avoiding undesirable damage to nearby arteries in the irradiated tissue.

Claims

1-32. -32. (canceled)

33. A method for treating at least one venous structure, comprising:

providing a particular electromagnetic radiation to a tissue region containing the at least one venous structure,

wherein the particular radiation has at least one property which effects the particular radiation to be more effectively absorbed by the at least one venous structure than by an artery present in the tissue region, and

wherein the particular radiation has a wavelength between about 685 nm and about 705 nm.

34. The method of claim 33, wherein the particular radiation has a wavelength between about 690 nm and about 700 nm.

35. The method of claim 33, wherein the particular radiation has a wavelength of about 694 nm.

36. The method of claim 33, wherein the particular radiation is provided using at least one of a pulsed dye laser, a wavelength-shifted Nd:

YAG laser, a frequency-doubled infrared laser, a high power diode laser array, or a fiber laser.

37. The method of claim 33, wherein the particular radiation is provided using a ruby laser.

38. The method of claim 33, wherein the particular radiation is provided using an intense pulsed light source.

39. The method of claim 38, further comprising filtering the radiation that is provided by the intense pulsed light source.

40. The method of claim 33, wherein the at least one venous structure is at least one of a port wine stain or a varicose vein.

41. The method of claim 33, wherein the particular electromagnetic radiation comprises a plurality of pulses, and wherein at least one of a duration or a fluence of each of the pulses is selected to avoid a formation of purpura in the tissue region.

42. The method of claim 33, wherein the particular electromagnetic radiation comprises a plurality of pulses, and wherein at least one of a duration or a fluence of each of the pulses is less than a duration or fluence of a preceding one of the pulses.

43. An apparatus for treating at least one venous structure, comprising:

a radiation source configured to provide a particular electromagnetic radiation to a biological tissue containing the at least one venous structure,

wherein the particular radiation has at least one property which effects the particular radiation to be more effectively absorbed by the at least one venous structure than by an artery present in the tissue region, and

wherein the particular radiation has a wavelength between about 685 nm and about 705 nm.

44. The apparatus of claim 43, wherein the particular radiation has a wavelength between about 690 nm and about 700 nm.

45. The apparatus of claim 43, wherein the particular radiation has a wavelength of about 694 nm.

46. The apparatus of claim 43, further comprising an optical arrangement structured to provide the particular radiation to at least one portion of the biological tissue.

47. The apparatus of claim 43, further comprising a control arrangement structured to at least one of control or adjust the at least one property of the particular radiation.

48. The apparatus of claim 43, wherein the at least one property is at least one of a pulse duration, a fluence, an intensity, or a wavelength.

49. The apparatus of claim 43, wherein the radiation source comprises at least one of a pulsed dye laser, a wavelength-shifted Nd:

YAG laser, a frequency-doubled infrared laser, a high power diode laser array, a fiber laser, or an intense pulsed light source.

50. The apparatus of claim 43, wherein the radiation source comprises an intense pulsed light source and a filter in communication with the intense pulsed light source.

51. The apparatus of claim 43, wherein the radiation source is configured to provide the particular electromagnetic radiation as a plurality of pulses, and wherein at least one of a duration or a fluence of each of the pulses is selectable to avoid a formation of purpura in the tissue region.

52. The apparatus of claim 43, wherein the radiation source is configured to provide the particular electromagnetic radiation as a plurality of pulses, and wherein at least one of a duration or a fluence of each of the pulses is less than the duration or the fluence of a preceding one of the pulses.