DOSING VAGAL NERVE STIMULATION THERAPY IN SYNCHRONIZATION WITH TRANSIENT EFFECTS

• US 20110224750A1
• Filed: 03/11/2011
• Published: 09/15/2011
• Est. Priority Date: 03/12/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Scheiner, Avram
• Granted Patent: US 8,818,508 B2
• Time in Patent Office: Days
• US Class Current: 607/17
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

The present disclosure is directed to a method of using an implantable medical device. One embodiment of the present disclosure comprises delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period. The transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient.

Claims

1. A method of using an implantable medical device comprising:

delivering electrical stimulation proximate nerve tissue of a patient during a transient physiological effect period separated by a recovery period, the transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient.

2. The method of claim 1 wherein the transient physiological effect period ends when a physiological condition indicates habituation to the electrical stimulation.

3. The method of claim 1 wherein the transient physiological effect period is less than or about equal to 5 seconds from a time in which a physiological condition is lower than a target physiological condition.

4. The method of claim 1 wherein after the recovery period, electrical stimulation has an increased level of efficacy.

5. The method of claim 1 further comprising:

determining a baseline physiological condition; and

determining a target physiological condition in response to determining the baseline physiological condition.

6. The method of claim 5 further comprising:

determining a first physiological condition is higher than a target physiological condition.

7. The method of claim 6 further comprising:

determining a second physiological condition is higher than the target physiological condition.

8. The method of claim 7 wherein the first physiological condition relates to one of a blood pressure, a heart rate, heart rate variability, and a sympathetic tone.

9. The method of claim 6 wherein the second physiological condition relates to one of a blood pressure, a heart rate, heart rate variability, and a sympathetic tone.

10. The method of claim 1 wherein the nerve tissue is a vagal nerve.

11. A method of using an implantable medical device comprising:

delivering electrical stimulation proximate nerve tissue of a patient;

determining a first physiological condition is higher than a target physiological condition;

determining an end to a transient physiological effect period;

ceasing electrical stimulation in response to determining the end of the transient physiological effect period;

determining an end of a recovery period;

determining a second physiological condition is higher than the target physiological condition; and

delivering automatically electrical stimulation proximate the nerve tissue in response to determining a second physiological condition is greater than the target physiological condition.

12. The method of claim 11 wherein the transient physiological effect period is less than or equal to 5 seconds from a time in which a patient'"'"'s physiological condition is better than the target physiological condition.

13. The method of claim 11 wherein the transient physiological effect period ends when a physiological condition indicates accommodation to the electrical stimulation.

14. The method of claim 11 wherein the first physiological condition relates to one of a blood pressure, a heart rate, heart rate variability, and a sympathetic tone.

15. The method of claim 11 wherein the second physiological condition relates to one of a blood pressure, a heart rate, heart rate variability, and a sympathetic tone.

16. A method of using an implantable medical device comprising:

determining a baseline heart rate;

determining a target heart rate;

determining a first heart rate is equal to or greater than the target heart rate;

initiating electrical stimulation proximate vagal nerve tissue of the patient, in response to determining the first heart rate is equal to or greater than the target heart rate;

determining a second heart rate is equal to or greater than the target heart in response to initiating electrical stimulation proximate vagal nerve tissue;

determining an end to a transient physiological effect period in response to determining the second heart rate;

ceasing electrical stimulation in response to determining the end of the transient physiological effect period;

determining an end of a recovery period in response to ceasing delivery of the electrical stimulation;

determining a third heart rate is equal to or greater than the target heart rate in response to determining the end of the recovery period; and

delivering automatically electrical stimulation proximate vagal nerve tissue of the patient, in response to determining a third heart rate is equal to or greater than the target heart rate.

17. The method of claim 16 wherein the transient physiological effect period is less than or equal to 5 seconds from a time in which a patient'"'"'s heart rate is detected at a heart rate lower than the target heart rate.

18. The method of claim 16 wherein the transient physiological effect period ends when a heart rate indicates accommodation to the electrical stimulation.

19. A method of using an implantable medical device comprising:

determining a first heart rate in a patient;

delivering electrical stimulation proximate vagal nerve tissue of the patient until a predetermined second heart rate is attained during a transient effect period, the second heart rate is lower than the first heart rate;

ceasing electrical stimulation in response to determining a second heart rate;

determining the heart rate starting to return to or completely returning to the first heart rate after a diminishing effect period;

delivering automatically electrical stimulation proximate vagal nerve tissue of the patient after a recovery period has ended; and

lowering the heart rate to the second heart rate.

20. The method of claim 19 further comprising determining an efficacy of the nerve tissue stimulation.

21. A method of obtaining a target heart rate through use of an implantable medical device comprising:

delivering electrical stimulation proximate vagal nerve tissue of a patient during a transient physiological effect period separated by a recovery period, the transient physiological effect period is when electrical stimulation has an increased level of efficacy and the recovery period is when additional electrical stimulation does not provide a beneficial physiological effect to the patient.